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2016 ; 48
(5
): 1868-76
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Corilagin suppresses cholangiocarcinoma progression through Notch signaling
pathway in vitro and in vivo
#MMPMID26935808
Gu Y
; Xiao L
; Ming Y
; Zheng Z
; Li W
Int J Oncol
2016[May]; 48
(5
): 1868-76
PMID26935808
show ga
Corilagin is a natural plant polyphenol tannic acid with antitumor,
anti-inflammatory, and anti-oxidative properties. However, the mechanisms of its
actions are largely unknown. Our group reported that corilagin could induce cell
inhibition in human breast cancer cell line MCF-7 and human liver hepatocellular
carcinoma cell lines HepG2. We report here that corilagin inhibits
cholangiocarcinoma (CCA) development through regulating Notch signaling pathway.
We found that, in vitro, corilagin inhibited CCA cell proliferation, migration
and invasion, promoted CCA cell apoptosis, and inhibited Notch1 and Notch
signaling pathway protein expression. Co-immunoprecipitation was used to
establish Notch intracellular domain (NICD) interaction with MAML1 and P300 in
CCA. Importantly, corilagin reduced Hes1 mRNA level through inhibiting Hes1
promoter activity. In nude mice, corilagin inhibited CCA growth and repressed the
expression of Notch1 and mTOR. These results indicate that corilagin may control
CCA cell growth by downregulating the expression of Notch1. Therefore, our
findings suggest that corilagin may have the potential to become a new
therapeutic drug for human CCA.