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10.1126/science.aaa4352 http://scihub22266oqcxt.onion/10.1126/science.aaa4352 C4809646!4809646!26339033     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 349 (6252): aaa4352 Nephropedia Template TP {{tp|p=26339033|t=2015. Neutrophil trails guide influenza-specific CD8+ T cells in the airways |pdf=|usr=}}{{26339033}} gab.com Text Neutrophil trails guide influenza-specific CD8+ T cells in the airways JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26339033 #FOAvip During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells is unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8+ T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditional knock-out mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8+ T cell recruitment and effector functions. Collectively, these results suggest neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8+ T cell migration and localization in influenza-infected tissues. Twit Text FOAVip Neutrophil trails guide influenza-specific CD8+ T cells in the airways ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26339033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26339033 #FOAvip English Wikipedia <ref>{{Cite pmid|26339033}}</ref> Neutrophil trails guide influenza-specific CD8+ T cells in the airways #MMPMID26339033 Lim K; Hyun YM; Lambert-Emo K; Capece T; Bae S; Miller R; Topham DJ; Kim M Science 2015[Sep]; 349 (6252): aaa4352 PMID26339033show ga During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells is unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8+ T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditional knock-out mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8+ T cell recruitment and effector functions. Collectively, these results suggest neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8+ T cell migration and localization in influenza-infected tissues. äNeutrophil trails guide influenza-specific CD8+ T cells in the airways(epmc).pdf DeepDyve Pubget Overpricing