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10.1371/journal.pone.0152687 http://scihub22266oqcxt.onion/10.1371/journal.pone.0152687 C4809592!4809592 !27019196     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27019196 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27019196 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2016 ; 11 (3 ): e0152687 Nephropedia Template TP {{tp|p=27019196 |t=2016. Long Non-Coding RNA MALAT1 Mediates Transforming Growth Factor Beta1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells |pdf=|usr=}}{{27019196 }} gab.com Text Long Non-Coding RNA MALAT1 Mediates Transforming Growth Factor Beta1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27019196 #FOAvip PURPOSE: To study the role of long non-coding RNA (lncRNA) MALAT1 in transforming growth factor beta 1 (TGF-?1)-induced epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells. METHODS: ARPE-19 cells were cultured and exposed to TGF-?1. The EMT of APRE-19 cells is confirmed by morphological change, as well as the increased expression of alpha-smooth muscle actin (?SMA) and fibronectin, and the down-regulation of E-cadherin and Zona occludin-1(ZO-1) at both mRNA and protein levels. The expression of lncRNA MALAT1 in RPE cells were detected by quantitative real-time PCR. Knockdown of MALAT1 was achieved by transfecting a small interfering RNA (SiRNA). The effect of inhibition of MALAT1 on EMT, migration, proliferation, and TGF? signalings were observed. MALAT1 expression was also detected in primary RPE cells incubated with proliferative vitreoretinopathy (PVR) vitreous samples. RESULTS: The expression of MALAT1 is significantly increased in RPE cells incubated with TGF?1. MALAT1 silencing attenuates TGF?1-induced EMT, migration, and proliferation of RPE cells, at least partially through activating Smad2/3 signaling. MALAT1 is also significantly increased in primary RPE cells incubated with PVR vitreous samples. CONCLUSION: LncRNA MALAT1 is involved in TGF?1-induced EMT of human RPE cells and provides new understandings for the pathogenesis of PVR. Twit Text FOAVip Long Non-Coding RNA MALAT1 Mediates Transforming Growth Factor Beta1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27019196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27019196 #FOAvip English Wikipedia <ref>{{Cite pmid|27019196 }}</ref> Long Non-Coding RNA MALAT1 Mediates Transforming Growth Factor Beta1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells #MMPMID27019196 Yang S ; Yao H ; Li M ; Li H ; Wang F PLoS One 2016[]; 11 (3 ): e0152687 PMID27019196 show ga PURPOSE: To study the role of long non-coding RNA (lncRNA) MALAT1 in transforming growth factor beta 1 (TGF-?1)-induced epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells. METHODS: ARPE-19 cells were cultured and exposed to TGF-?1. The EMT of APRE-19 cells is confirmed by morphological change, as well as the increased expression of alpha-smooth muscle actin (?SMA) and fibronectin, and the down-regulation of E-cadherin and Zona occludin-1(ZO-1) at both mRNA and protein levels. The expression of lncRNA MALAT1 in RPE cells were detected by quantitative real-time PCR. Knockdown of MALAT1 was achieved by transfecting a small interfering RNA (SiRNA). The effect of inhibition of MALAT1 on EMT, migration, proliferation, and TGF? signalings were observed. MALAT1 expression was also detected in primary RPE cells incubated with proliferative vitreoretinopathy (PVR) vitreous samples. RESULTS: The expression of MALAT1 is significantly increased in RPE cells incubated with TGF?1. MALAT1 silencing attenuates TGF?1-induced EMT, migration, and proliferation of RPE cells, at least partially through activating Smad2/3 signaling. MALAT1 is also significantly increased in primary RPE cells incubated with PVR vitreous samples. CONCLUSION: LncRNA MALAT1 is involved in TGF?1-induced EMT of human RPE cells and provides new understandings for the pathogenesis of PVR. |Actins/metabolism [MESH] |Cadherins/metabolism [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Cells, Cultured [MESH] |Down-Regulation/drug effects [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Fibronectins/metabolism [MESH] |Humans [MESH] |RNA Interference [MESH] |RNA, Long Noncoding/antagonists & inhibitors/genetics/*metabolism [MESH] |Retinal Pigment Epithelium/cytology/metabolism [MESH] |Signal Transduction/drug effects [MESH] |Smad2 Protein/metabolism [MESH] |Smad3 Protein/metabolism [MESH] |Transcription Factors/genetics/metabolism [MESH] |Transforming Growth Factor beta1/*pharmacology [MESH] |Up-Regulation/drug effects [MESH] |Vitreoretinopathy, Proliferative/metabolism/pathology [MESH]Long Non-Coding RNA MALAT1 Mediates Transforming Growth Factor Beta1-I(epmc).pdf DeepDyve Pubget Overpricing