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10.1007/s00018-015-1833-2 http://scihub22266oqcxt.onion/10.1007/s00018-015-1833-2 C4809369!4809369 !25595304     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25595304 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Life+Sci 2015 ; 72 (9 ): 1741-57 Nephropedia Template TP {{tp|p=25595304 |t=2015. Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network |pdf=|usr=}}{{25595304 }} gab.com Text Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=25595304 #FOAvip Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the capacity to generate any type of cell in the body, and therefore not only hold great promise for tissue repair and regeneration, but also provide a powerful tool for modeling human disease and understanding biological development. In order to fulfill the full potential of ESCs, it is critical to understand how ESC fate, whether to self-renew or to differentiate into specialized cells, is regulated. On the molecular level, ESC fate is controlled by the intracellular transcriptional regulatory networks that respond to various extrinsic signaling stimuli. In this review, we discuss and compare important signaling pathways in the self-renewal and differentiation of mouse, rat, and human ESCs with an emphasis on how these pathways integrate into ESC-specific transcription circuitries. This will be beneficial for understanding the common and conserved mechanisms that govern self-renewal, and for developing novel culture conditions that support ESC derivation and maintenance. Twit Text FOAVip Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=25595304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25595304 #FOAvip English Wikipedia <ref>{{Cite pmid|25595304 }}</ref> Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network #MMPMID25595304 Huang G ; Ye S ; Zhou X ; Liu D ; Ying QL Cell Mol Life Sci 2015[May]; 72 (9 ): 1741-57 PMID25595304 show ga Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the capacity to generate any type of cell in the body, and therefore not only hold great promise for tissue repair and regeneration, but also provide a powerful tool for modeling human disease and understanding biological development. In order to fulfill the full potential of ESCs, it is critical to understand how ESC fate, whether to self-renew or to differentiate into specialized cells, is regulated. On the molecular level, ESC fate is controlled by the intracellular transcriptional regulatory networks that respond to various extrinsic signaling stimuli. In this review, we discuss and compare important signaling pathways in the self-renewal and differentiation of mouse, rat, and human ESCs with an emphasis on how these pathways integrate into ESC-specific transcription circuitries. This will be beneficial for understanding the common and conserved mechanisms that govern self-renewal, and for developing novel culture conditions that support ESC derivation and maintenance. |*Gene Regulatory Networks [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Cell Proliferation [MESH] |Embryonic Stem Cells/*cytology/*metabolism [MESH]Molecular basis of embryonic stem cell self-renewal: from signaling pa(epmc).pdf DeepDyve Pubget Overpricing