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10.1126/science.aac4919 http://scihub22266oqcxt.onion/10.1126/science.aac4919 C4809261!4809261!26184917     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 349 (6248): 643-6 Nephropedia Template TP {{tp|p=26184917|t=2015. T cell help controls the speed of the cell cycle in germinal center B cells |pdf=|usr=}}{{26184917}} gab.com Text T cell help controls the speed of the cell cycle in germinal center B cells JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26184917 #FOAvip The germinal center (GC) is a microanatomical compartment wherein high affinity antibody-producing B cells are selectively expanded. B cells proliferate and mutate their antibody genes in the dark zone (DZ) of the GC, and are then selected by T cells in the light zone (LZ) on the basis of affinity. Here we show that T cell help regulates the speed of cell cycle phase transitions and DNA replication of GC B cells. Genome sequencing and single-molecule analyses revealed that T cell help shortens S phase by regulating replication fork progression while preserving the relative order of replication origin activation. Thus, high affinity GC B cells are selected by a mechanism that involves prolonged dwell time in the DZ where selected cells undergo accelerated cell cycles. Twit Text FOAVip T cell help controls the speed of the cell cycle in germinal center B cells ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26184917 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26184917 #FOAvip English Wikipedia <ref>{{Cite pmid|26184917}}</ref> T cell help controls the speed of the cell cycle in germinal center B cells #MMPMID26184917 Gitlin AD; Mayer CT; Oliveira TY; Shulman Z; Jones MJ; Koren A; Nussenzweig MC Science 2015[Aug]; 349 (6248): 643-6 PMID26184917show ga The germinal center (GC) is a microanatomical compartment wherein high affinity antibody-producing B cells are selectively expanded. B cells proliferate and mutate their antibody genes in the dark zone (DZ) of the GC, and are then selected by T cells in the light zone (LZ) on the basis of affinity. Here we show that T cell help regulates the speed of cell cycle phase transitions and DNA replication of GC B cells. Genome sequencing and single-molecule analyses revealed that T cell help shortens S phase by regulating replication fork progression while preserving the relative order of replication origin activation. Thus, high affinity GC B cells are selected by a mechanism that involves prolonged dwell time in the DZ where selected cells undergo accelerated cell cycles. äT cell help controls the speed of the cell cycle in germinal center B (epmc).pdf DeepDyve Pubget Overpricing