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10.1146/annurev-neuro-071714-034019 http://scihub22266oqcxt.onion/10.1146/annurev-neuro-071714-034019 C4809143!4809143!25840006     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Neurosci 2015 ; 38 (ä): 105-25 Nephropedia Template TP {{tp|p=25840006|t=2015. NEUROLOGICAL ASPECTS OF HUMAN GLYCOSYLATION DISORDERS |pdf=|usr=}}{{25840006}} gab.com Text NEUROLOGICAL ASPECTS OF HUMAN GLYCOSYLATION DISORDERS JO: Annu Rev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25840006 #FOAvip This review will present principles of glycosylation, describe the relevant glycosylation pathways and their related disorders, and highlight some of the neurological aspects and issues that continue to challenge researchers. Over 100 rare human genetic disorders that result from deficiencies in the different glycosylation pathways are known today. Most of these disorders impact the central and/or peripheral nervous systems. Patients typically have developmental delay/intellectual disability, hypotonia, seizures, neuropathy, and metabolic abnormalities in multiple organ systems. Between these disorders there is great clinical diversity because all cell types differentially glycosylate proteins and lipids. The patients have hundreds of mis-glycosylated products afflicting a myriad of processes including cell signaling, cell-cell interaction and cell migration. This vast complexity in glycan composition and function, along with limited analytic tools has impeded the identification of key glycosylated molecules that cause pathologies, and to date few critical target proteins have been pinpointed. Twit Text FOAVip NEUROLOGICAL ASPECTS OF HUMAN GLYCOSYLATION DISORDERS ????Annu Rev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25840006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25840006 #FOAvip English Wikipedia <ref>{{Cite pmid|25840006}}</ref> NEUROLOGICAL ASPECTS OF HUMAN GLYCOSYLATION DISORDERS #MMPMID25840006 Freeze HH; Eklund EA; Ng BG; Patterson MC Annu Rev Neurosci 2015[Jul]; 38 (ä): 105-25 PMID25840006show ga This review will present principles of glycosylation, describe the relevant glycosylation pathways and their related disorders, and highlight some of the neurological aspects and issues that continue to challenge researchers. Over 100 rare human genetic disorders that result from deficiencies in the different glycosylation pathways are known today. Most of these disorders impact the central and/or peripheral nervous systems. Patients typically have developmental delay/intellectual disability, hypotonia, seizures, neuropathy, and metabolic abnormalities in multiple organ systems. Between these disorders there is great clinical diversity because all cell types differentially glycosylate proteins and lipids. The patients have hundreds of mis-glycosylated products afflicting a myriad of processes including cell signaling, cell-cell interaction and cell migration. This vast complexity in glycan composition and function, along with limited analytic tools has impeded the identification of key glycosylated molecules that cause pathologies, and to date few critical target proteins have been pinpointed. äNEUROLOGICAL ASPECTS OF HUMAN GLYCOSYLATION DISORDERS (epmc).pdf DeepDyve Pubget Overpricing