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10.1111/jnc.13250 http://scihub22266oqcxt.onion/10.1111/jnc.13250 C4809142!4809142!26190522     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurochem 2015 ; 135 (2): 309-22 Nephropedia Template TP {{tp|p=26190522|t=2015. Interferon Gamma Induces Protective Non-Canonical Signaling Pathways in Primary Neurons |pdf=|usr=}}{{26190522}} gab.com Text Interferon Gamma Induces Protective Non-Canonical Signaling Pathways in Primary Neurons JO: J Neurochem http://www.kidney.de/pget.php?&tw=1&pmid=26190522 #FOAvip The signal transduction molecule, Stat1, is critical for the expression of type I and II interferon (IFN)-responsive genes in most cells; however, we previously showed that primary hippocampal mouse neurons express low basal Stat1, with delayed and attenuated expression of IFN-responsive genes. Moreover, IFN?-dependent resolution of a neurotropic viral challenge in permissive mice is Stat1-independent. Here, we show that exogenous INF? has no deleterious impact on neuronal viability, and staurosporine-induced apoptosis in neurons is significantly blunted by the addition of INF?, suggesting that INF? confers a pro-survival signal in neurons. To identify the pathways induced by INF? in neurons, the activation of alternative signal transducers associated with INF? signaling was assessed. Rapid and pronounced activation of extracellular signal regulated kinase (Erk1/2) was observed in neurons, compared to a modest response in fibroblasts. Moreover, the absence of Stat1 in primary fibroblasts led to enhanced Erk activation following IFN? addition, implying that the cell-specific availability of signal transducers can diversify the cellular response following IFN engagement. Twit Text FOAVip Interferon Gamma Induces Protective Non-Canonical Signaling Pathways in Primary Neurons ????J Neurochem http://www.kidney.de/pget.php?&tw=1&pmid=26190522 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26190522 #FOAvip English Wikipedia <ref>{{Cite pmid|26190522}}</ref> Interferon Gamma Induces Protective Non-Canonical Signaling Pathways in Primary Neurons #MMPMID26190522 O'Donnell LA; Henkins KM; Kulkarni A; Matullo CM; Balachandran S; Pattisapu AK; Rall GF J Neurochem 2015[Oct]; 135 (2): 309-22 PMID26190522show ga The signal transduction molecule, Stat1, is critical for the expression of type I and II interferon (IFN)-responsive genes in most cells; however, we previously showed that primary hippocampal mouse neurons express low basal Stat1, with delayed and attenuated expression of IFN-responsive genes. Moreover, IFN?-dependent resolution of a neurotropic viral challenge in permissive mice is Stat1-independent. Here, we show that exogenous INF? has no deleterious impact on neuronal viability, and staurosporine-induced apoptosis in neurons is significantly blunted by the addition of INF?, suggesting that INF? confers a pro-survival signal in neurons. To identify the pathways induced by INF? in neurons, the activation of alternative signal transducers associated with INF? signaling was assessed. Rapid and pronounced activation of extracellular signal regulated kinase (Erk1/2) was observed in neurons, compared to a modest response in fibroblasts. Moreover, the absence of Stat1 in primary fibroblasts led to enhanced Erk activation following IFN? addition, implying that the cell-specific availability of signal transducers can diversify the cellular response following IFN engagement. äInterferon Gamma Induces Protective Non-Canonical Signaling Pathways i(epmc).pdf DeepDyve Pubget Overpricing