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10.1021/acs.analchem.5b02803

http://scihub22266oqcxt.onion/10.1021/acs.analchem.5b02803
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C4809138!4809138!26491962
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suck abstract from ncbi


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pmid26491962      Anal+Chem 2015 ; 87 (22): 11383-8
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  • Quantification of Borrelia burgdorferi membrane proteins in human serum is a new concept for detection of bacterial infection #MMPMID26491962
  • Cheung CSF; Anderson KW; Villatoro Benitez KY; Soloski MJ; Aucott JN; Phinney KW; Turko IV
  • Anal Chem 2015[Nov]; 87 (22): 11383-8 PMID26491962show ga
  • The B. burgdorferi spirochete is the causative agent of Lyme disease, the most common tick-borne disease in the United States. The low abundance of bacterial proteins in human serum during infection imposes a challenge for early proteomic detection of Lyme disease. To address this challenge, we propose to detect membrane proteins released from bacteria due to disruption of their plasma membrane triggered by the innate immune system. These membrane proteins can be separated from the bulk of serum proteins by high-speed centrifugation causing substantial sample enrichment prior to targeted protein quantification using multiple reaction monitoring mass spectrometry. This new approach was first applied to detection of B. burgdorferi membrane proteins supplemented in human serum. Our results indicated that detection of B. burgdorferi membrane proteins, which are ? 107 lower in abundance than major serum proteins, is feasible. Therefore quantitative analysis was also carried out for serum samples from three patients with acute Lyme disease. We were able to demonstrate the detection of ospA, the major B. burgdorferi lipoprotein at the level of 4.0 fmol of ospA/mg of serum protein. The results confirm the concept and suggest that the proposed approach can be expanded to detect other bacterial infections in humans, particularly where existing diagnostics are unreliable.
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