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10.1016/j.ccc.2015.11.004 http://scihub22266oqcxt.onion/10.1016/j.ccc.2015.11.004 C4808565!4808565!27016162     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care+Clin 2016 ; 32 (2): 203-12 Nephropedia Template TP {{tp|p=27016162|t=2016. The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness |pdf=|usr=}}{{27016162}} gab.com Text The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness JO: Crit Care Clin http://www.kidney.de/pget.php?&tw=1&pmid=27016162 #FOAvip All elements of the gut ? the epithelium, the immune system, and the microbiome ? are impacted by critical illness and can, in turn, propagate a pathologic host response leading to multiple organ dysfunction syndrome. Preclinical studies have demonstrated that this can occur by release of toxic gut-derived substances into the mesenteric lymph where they can cause distant damage. Further, intestinal integrity is compromised in critical illness with increases in apoptosis and permeability. There is also increasing recognition that microbes alter their behavior and can become virulent based upon host environmental cues. Gut failure is common in critically ill patients; however, therapeutics targeting the gut have proven to be challenging to implement at the bedside. Numerous strategies to manipulate the microbiome have recently been used with varying success in the ICU. Twit Text FOAVip The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness ????Crit Care Clin http://www.kidney.de/pget.php?&tw=1&pmid=27016162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27016162 #FOAvip English Wikipedia <ref>{{Cite pmid|27016162}}</ref> The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness #MMPMID27016162 Klingensmith NJ; Coopersmith CM Crit Care Clin 2016[Apr]; 32 (2): 203-12 PMID27016162show ga All elements of the gut ? the epithelium, the immune system, and the microbiome ? are impacted by critical illness and can, in turn, propagate a pathologic host response leading to multiple organ dysfunction syndrome. Preclinical studies have demonstrated that this can occur by release of toxic gut-derived substances into the mesenteric lymph where they can cause distant damage. Further, intestinal integrity is compromised in critical illness with increases in apoptosis and permeability. There is also increasing recognition that microbes alter their behavior and can become virulent based upon host environmental cues. Gut failure is common in critically ill patients; however, therapeutics targeting the gut have proven to be challenging to implement at the bedside. Numerous strategies to manipulate the microbiome have recently been used with varying success in the ICU. äThe Gut as the Motor of Multiple Organ Dysfunction in Critical Illness(epmc).pdf DeepDyve Pubget Overpricing