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10.1053/j.semperi.2015.12.004

http://scihub22266oqcxt.onion/10.1053/j.semperi.2015.12.004
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C4808469!4808469!26778236
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suck abstract from ncbi


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pmid26778236      Semin+Perinatol 2016 ; 40 (3): 160-73
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  • Pharmacologic Strategies in Neonatal Pulmonary Hypertension other than Nitric Oxide #MMPMID26778236
  • Lakshminrusimha S; Mathew B; Leach CL
  • Semin Perinatol 2016[Apr]; 40 (3): 160-73 PMID26778236show ga
  • Inhaled nitric oxide (iNO) is approved for use in persistent pulmonary hypertension of the newborn (PPHN) but does not lead to sustained improvement in oxygenation in a third of patients with PPHN. Inhaled NO is less effective in the management of PPHN secondary to congenital diaphragmatic hernia (CDH), extreme prematurity and bronchopulmonary dysplasia (BPD). Intravenous pulmonary vasodilators such as prostacyclin, alprostadil, sildenafil and milrinone have been successfully used in PPHN resistant to iNO. Oral pulmonary vasodilators such as endothelin-receptor antagonist bosentan and phosphodiesterase-5 inhibitors such as sildenafil and tadalafil are used both during acute and chronic phase of PPHN. In the absence of infection, glucocorticoids may also be effective in PPHN. Many of these pharmacologic agents are not approved for use in PPHN and our knowledge is based on case reports and small trials. Large multicenter randomized controlled trials with long-term follow-up are required to evaluate pharmacologic strategies in PPHN.
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