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10.1016/j.cell.2016.01.021 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.01.021 C4808403!4808403!26924577     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (1): 100-10 Nephropedia Template TP {{tp|p=26924577|t=2016. Cytotoxic T cells use mechanical force to potentiate target cell killing |pdf=|usr=}}{{26924577}} gab.com Text Cytotoxic T cells use mechanical force to potentiate target cell killing JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26924577 #FOAvip The immunological synapse formed between a cytotoxic T lymphocyte (CTL) and an infected or transformed target cell is a physically active structure capable of exerting mechanical force. Here, we investigated whether synaptic forces promote the destruction of target cells. CTLs kill by secreting toxic proteases and the pore forming protein perforin into the synapse. Biophysical experiments revealed a striking correlation between the magnitude of force exertion across the synapse and the speed of perforin pore formation on the target cell, implying that force potentiates cytotoxicity by enhancing perforin activity. Consistent with this interpretation, we found that increasing target cell tension augmented pore formation by perforin and killing by CTLs. Our data also indicate that CTLs coordinate perforin release and force exertion in space and time. These results reveal an unappreciated physical dimension to lymphocyte function and demonstrate that cells use mechanical forces to control the activity of outgoing chemical signals. Twit Text FOAVip Cytotoxic T cells use mechanical force to potentiate target cell killing ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26924577 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26924577 #FOAvip English Wikipedia <ref>{{Cite pmid|26924577}}</ref> Cytotoxic T cells use mechanical force to potentiate target cell killing #MMPMID26924577 Basu R; Whitlock BM; Husson J; Le Floc?h A; Jin W; Oyler-Yaniv A; Dotiwala F; Giannone G; Hivroz C; Biais N; Lieberman J; Kam LC; Huse M Cell 2016[Mar]; 165 (1): 100-10 PMID26924577show ga The immunological synapse formed between a cytotoxic T lymphocyte (CTL) and an infected or transformed target cell is a physically active structure capable of exerting mechanical force. Here, we investigated whether synaptic forces promote the destruction of target cells. CTLs kill by secreting toxic proteases and the pore forming protein perforin into the synapse. Biophysical experiments revealed a striking correlation between the magnitude of force exertion across the synapse and the speed of perforin pore formation on the target cell, implying that force potentiates cytotoxicity by enhancing perforin activity. Consistent with this interpretation, we found that increasing target cell tension augmented pore formation by perforin and killing by CTLs. Our data also indicate that CTLs coordinate perforin release and force exertion in space and time. These results reveal an unappreciated physical dimension to lymphocyte function and demonstrate that cells use mechanical forces to control the activity of outgoing chemical signals. äCytotoxic T cells use mechanical force to potentiate target cell killi(epmc).pdf DeepDyve Pubget Overpricing