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2016 ; 9
(ä): 1-9
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Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in
Diabetes and Its Complications
#MMPMID27042090
Zheng H
; Wu J
; Jin Z
; Yan LJ
Biochem Insights
2016[]; 9
(ä): 1-9
PMID27042090
show ga
Diabetes and its complications are hyperglycemic toxicity diseases. Many
metabolic pathways in this array of diseases become aberrant, which is
accompanied with a variety of posttranslational protein modifications that in
turn reflect diabetic glucotoxicity. In this review, we summarize some of the
most widely studied protein modifications in diabetes and its complications.
These modifications include glycation, carbonylation, nitration, cysteine
S-nitrosylation, acetylation, sumoylation, ADP-ribosylation, O-GlcNAcylation, and
succination. All these posttranslational modifications can be significantly
attributed to oxidative stress and/or carbon stress induced by diabetic redox
imbalance that is driven by activation of pathways, such as the polyol pathway
and the ADP-ribosylation pathway. Exploring the nature of these modifications
should facilitate our understanding of the pathological mechanisms of diabetes
and its associated complications.