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2015 ; 90
(2
): 202-8
Nephropedia Template TP
gab.com Text
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English Wikipedia
Correlation of geomagnetic activity with implantable cardioverter defibrillator
shocks and antitachycardia pacing
#MMPMID25659238
Ebrille E
; Konecny T
; Konecny D
; Spacek R
; Jones P
; Ambroz P
; DeSimone CV
; Powell BD
; Hayes DL
; Friedman PA
; Asirvatham SJ
Mayo Clin Proc
2015[Feb]; 90
(2
): 202-8
PMID25659238
show ga
OBJECTIVE: To investigate a potential relationship between implantable
cardioverter defibrillator (ICD) therapies and daily geomagnetic activity (GMA)
recorded in a large database. PATIENTS AND METHODS: The ALTITUDE database,
derived from the Boston Scientific LATITUDE remote monitoring system, was
retrospectively analyzed for the frequency of ICD therapies. Daily GMA was
expressed as the planetary K-index and the integrated A-index and was graded as
levels I (quiet), II (unsettled), III (active), and IV (storm). RESULTS: A daily
mean ± SD of 59,468±11,397 patients were monitored between January 1, 2009, and
May 15, 2012. The distribution of days according to GMA was as follows: level I,
924/1231 (75%); level II, 226/1231 (18%); level III, 60/1231 (5%); and level IV,
21/1231 (2%). The daily mean ± SD numbers of ICD shocks received per 1000 active
patients in the database were 1.29±0.47, 1.17±0.46, 1.03±0.37, and 0.94±0.29 on
level I, II, III, and IV days, respectively; the daily mean ± SD sums of shocks
and antitachycardia pacing therapies were 9.29±2.86, 8.46±2.45, 7.92±1.80, and
7.83±2.28 on quiet, unsettled, active, and storm days, respectively. A
significant inverse relationship between GMA and frequency of ICD therapies was
identified, with the most pronounced difference between level I and level IV days
(P<.001 for shocks; P=.008 for shocks + antitachycardia pacing). CONCLUSION: In a
large-scale cohort analysis, ICD therapies were delivered less frequently on days
of higher GMA, confirming the previous pilot data and suggesting that higher GMA
does not pose an increased risk of arrhythmias using ICD therapies as a surrogate
marker. Further studies are needed to gain an in-depth understanding of the
underlying mechanisms.