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10.1371/journal.pone.0152203 http://scihub22266oqcxt.onion/10.1371/journal.pone.0152203 C4806979!4806979 !27011216     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27011216 &cmd=llinks): Failed to open stream: HTTP request failed! 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Epidemiology of Histologically Proven Glomerulonephritis in Africa: A Systematic Review and Meta-Analysis |pdf=|usr=}}{{27011216 }} gab.com Text Epidemiology of Histologically Proven Glomerulonephritis in Africa: A Systematic Review and Meta-Analysis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27011216 #FOAvip BACKGROUND AND AIM: Glomerulonephritis (GN) is a leading cause of end-stage renal disease (ESRD) in Africa. Data on epidemiology and outcomes of glomerular diseases from Africa is still limited. We conducted a systematic review on the epidemiology of histologically proven glomerular diseases in Africa between 1980 and 2014. MATERIALS AND METHODS: We searched literature using PubMed, AfricaWide, the Cumulative Index to Nursing and Allied Health Literature on EBSCO Host, Scopus, African Journals online databases, and the African Index Medicus, for relevant studies. The review was conducted using standard methods and frameworks using only biopsy-confirmed data. RESULTS: Twenty four (24) studies comprising 12,093 reported biopsies from 13 countries were included in this analysis. The median number of biopsies per study was 127.0 (50-4436), most of the studies (70.0%) originated from North Africa and the number of performed kidney biopsies varied from 5.2 to 617 biopsies/year. Nephrotic syndrome was the commonest indication of renal biopsy. The frequency of reported primary pathologic patterns included, minimal change disease (MCD); 16.5% (95%CI: 11.2-22.6), focal segmental glomerulosclerosis (FSGS); 15.9% (11.3-21.1), mesangiocapillary GN (MCGN); 11.8% (9.2-14.6), crescentic GN; 2.0% (0.9-3.5) and IgA nephropathy 2.8% (1.3-4.9). Glomerular diseases related to hepatitis B and systemic lupus erythematosus had the highest prevalence among assessed secondary diseases: 8.4% (2.0-18.4) and 7.7% (4.5-11.7) respectively. There was no evidence of publication bias and regional differences were seen mostly for secondary GNs. CONCLUSIONS: Glomerular diseases remain poorly characterized in sub-Saharan Africa due to declining renal biopsy rates and consequent paucity of data on pathologic patterns of key renal diseases. Development of renal biopsy registries in Africa is likely to enable adequate characterization of the prevalence and patterns of glomerular diseases; this could have a positive impact on chronic kidney disease evaluation and treatment in the African continent since most glomerulopathies are amenable to treatment. Twit Text FOAVip Epidemiology of Histologically Proven Glomerulonephritis in Africa: A Systematic Review and Meta-Analysis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27011216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27011216 #FOAvip English Wikipedia <ref>{{Cite pmid|27011216 }}</ref> Epidemiology of Histologically Proven Glomerulonephritis in Africa: A Systematic Review and Meta-Analysis #MMPMID27011216 Okpechi IG ; Ameh OI ; Bello AK ; Ronco P ; Swanepoel CR ; Kengne AP PLoS One 2016[]; 11 (3 ): e0152203 PMID27011216 show ga BACKGROUND AND AIM: Glomerulonephritis (GN) is a leading cause of end-stage renal disease (ESRD) in Africa. Data on epidemiology and outcomes of glomerular diseases from Africa is still limited. We conducted a systematic review on the epidemiology of histologically proven glomerular diseases in Africa between 1980 and 2014. MATERIALS AND METHODS: We searched literature using PubMed, AfricaWide, the Cumulative Index to Nursing and Allied Health Literature on EBSCO Host, Scopus, African Journals online databases, and the African Index Medicus, for relevant studies. The review was conducted using standard methods and frameworks using only biopsy-confirmed data. RESULTS: Twenty four (24) studies comprising 12,093 reported biopsies from 13 countries were included in this analysis. The median number of biopsies per study was 127.0 (50-4436), most of the studies (70.0%) originated from North Africa and the number of performed kidney biopsies varied from 5.2 to 617 biopsies/year. Nephrotic syndrome was the commonest indication of renal biopsy. The frequency of reported primary pathologic patterns included, minimal change disease (MCD); 16.5% (95%CI: 11.2-22.6), focal segmental glomerulosclerosis (FSGS); 15.9% (11.3-21.1), mesangiocapillary GN (MCGN); 11.8% (9.2-14.6), crescentic GN; 2.0% (0.9-3.5) and IgA nephropathy 2.8% (1.3-4.9). Glomerular diseases related to hepatitis B and systemic lupus erythematosus had the highest prevalence among assessed secondary diseases: 8.4% (2.0-18.4) and 7.7% (4.5-11.7) respectively. There was no evidence of publication bias and regional differences were seen mostly for secondary GNs. CONCLUSIONS: Glomerular diseases remain poorly characterized in sub-Saharan Africa due to declining renal biopsy rates and consequent paucity of data on pathologic patterns of key renal diseases. Development of renal biopsy registries in Africa is likely to enable adequate characterization of the prevalence and patterns of glomerular diseases; this could have a positive impact on chronic kidney disease evaluation and treatment in the African continent since most glomerulopathies are amenable to treatment. |Africa/epidemiology [MESH] |Biopsy [MESH] |Female [MESH] |Glomerulonephritis/*epidemiology/pathology [MESH] |Glomerulosclerosis, Focal Segmental/*epidemiology/pathology [MESH] |Hepatitis B/epidemiology/pathology [MESH] |Humans [MESH] |Kidney Failure, Chronic/*epidemiology/pathology [MESH] |Kidney/pathology [MESH] |Male [MESH]Epidemiology of Histologically Proven Glomerulonephritis in Africa: A (epmc).pdf DeepDyve Pubget Overpricing