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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Am+Acad+Dermatol 2015 ; 73 (5): 777-84 Nephropedia Template TP
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Clinical and dermoscopic features of Atypical Spitz Tumors: a multi-center, retrospective, case-control study #MMPMID26475536
Moscarella E; Lallas A; Kyrgidis A; Ferrara G; Longo C; Scalvenzi M; Staibano S; Carrera C; Díaz AM; Broganelli P; Tomasini C; Cavicchini S; Gianotti R; Puig S; Malvehy J; Zaballos P; Pellacani G; Argenziano G
J Am Acad Dermatol 2015[Nov]; 73 (5): 777-84 PMID26475536show ga
Background: Few studies have described the clinical and dermoscopic features of atypical Spitz tumors (AST). Objective: To describe the clinical and dermoscopic features of a series of AST as compared to those of conventional Spitz nevi (SN). Methods: Multicenter, retrospective, case-control study, analyzing the clinical and dermoscopic characteristics of 55 AST and 110 SN that were excised and diagnosed histopathologically. Results: The majority of AST presented clinically as a plaque or nodule, dermoscopically typified by a multicomponent or nonspecific pattern. A proportion of lesions (16.4%) exhibited the typical non pigmented spitzoid pattern of dotted vessels and white lines under dermoscopy.Nodularity, ulceration, linear vessels, polymorphic vessels, white lines, and blue/white veil were associated with AST by univariate analysis, but only nodularity and white lines remained significant after multivariate analysis. In contrast, a pigmented typical spitzoid pattern was a potent predictor of SN, associated with 6.5-fold increased probability. Limitations: Differentiation from spitzoid melanoma and other non melanocytic lesions was not investigated. Conclusion: Atypical Spitz tumors are polymorphic melanocytic proliferations with a nodular clinical appearance. Dermoscopically they demonstrate a multicomponent and nonspecific pattern. A typical non pigmented spitzoid pattern on dermoscopy (with dotted vessels and white lines) does not exclude AST.