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2015 ; 73
(5
): 777-84
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Clinical and dermoscopic features of atypical Spitz tumors: A multicenter,
retrospective, case-control study
#MMPMID26475536
Moscarella E
; Lallas A
; Kyrgidis A
; Ferrara G
; Longo C
; Scalvenzi M
; Staibano S
; Carrera C
; Díaz MA
; Broganelli P
; Tomasini C
; Cavicchini S
; Gianotti R
; Puig S
; Malvehy J
; Zaballos P
; Pellacani G
; Argenziano G
J Am Acad Dermatol
2015[Nov]; 73
(5
): 777-84
PMID26475536
show ga
BACKGROUND: Few studies have described the clinical and dermoscopic features of
atypical Spitz tumors. OBJECTIVE: We sought to describe the clinical and
dermoscopic features of a series of atypical Spitz tumors as compared with those
of conventional Spitz nevi. METHODS: This was a multicenter, retrospective,
case-control study, analyzing the clinical and dermoscopic characteristics of 55
atypical Spitz tumors and 110 Spitz nevi that were excised and diagnosed
histopathologically. RESULTS: The majority of atypical Spitz tumors presented
clinically as a plaque or nodule, dermoscopically typified by a multicomponent or
nonspecific pattern. A proportion of lesions (16.4%) exhibited the typical
nonpigmented Spitzoid pattern of dotted vessels and white lines under dermoscopy.
Nodularity, ulceration, linear vessels, polymorphic vessels, white lines, and
blue-white veil were associated with atypical Spitz tumors by univariate
analysis, but only nodularity and white lines remained significant after
multivariate analysis. In contrast, a pigmented typical Spitzoid pattern was a
potent predictor of Spitz nevi, associated with 6.5-fold increased probability.
LIMITATIONS: Differentiation from Spitzoid melanoma and other nonmelanocytic
lesions was not investigated. CONCLUSION: Atypical Spitz tumors are polymorphic
melanocytic proliferations with a nodular clinical appearance. Dermoscopically
they demonstrate a multicomponent and nonspecific pattern. A typical nonpigmented
Spitzoid pattern on dermoscopy (with dotted vessels and white lines) does not
exclude atypical Spitz tumors.
|*Dermoscopy
[MESH]
|Adolescent
[MESH]
|Adult
[MESH]
|Case-Control Studies
[MESH]
|Diagnosis, Differential
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Male
[MESH]
|Nevus, Epithelioid and Spindle Cell/*pathology
[MESH]