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10.1016/j.jaad.2015.08.018

http://scihub22266oqcxt.onion/10.1016/j.jaad.2015.08.018
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suck abstract from ncbi


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pmid26475536
      J+Am+Acad+Dermatol 2015 ; 73 (5 ): 777-84
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  • Clinical and dermoscopic features of atypical Spitz tumors: A multicenter, retrospective, case-control study #MMPMID26475536
  • Moscarella E ; Lallas A ; Kyrgidis A ; Ferrara G ; Longo C ; Scalvenzi M ; Staibano S ; Carrera C ; Díaz MA ; Broganelli P ; Tomasini C ; Cavicchini S ; Gianotti R ; Puig S ; Malvehy J ; Zaballos P ; Pellacani G ; Argenziano G
  • J Am Acad Dermatol 2015[Nov]; 73 (5 ): 777-84 PMID26475536 show ga
  • BACKGROUND: Few studies have described the clinical and dermoscopic features of atypical Spitz tumors. OBJECTIVE: We sought to describe the clinical and dermoscopic features of a series of atypical Spitz tumors as compared with those of conventional Spitz nevi. METHODS: This was a multicenter, retrospective, case-control study, analyzing the clinical and dermoscopic characteristics of 55 atypical Spitz tumors and 110 Spitz nevi that were excised and diagnosed histopathologically. RESULTS: The majority of atypical Spitz tumors presented clinically as a plaque or nodule, dermoscopically typified by a multicomponent or nonspecific pattern. A proportion of lesions (16.4%) exhibited the typical nonpigmented Spitzoid pattern of dotted vessels and white lines under dermoscopy. Nodularity, ulceration, linear vessels, polymorphic vessels, white lines, and blue-white veil were associated with atypical Spitz tumors by univariate analysis, but only nodularity and white lines remained significant after multivariate analysis. In contrast, a pigmented typical Spitzoid pattern was a potent predictor of Spitz nevi, associated with 6.5-fold increased probability. LIMITATIONS: Differentiation from Spitzoid melanoma and other nonmelanocytic lesions was not investigated. CONCLUSION: Atypical Spitz tumors are polymorphic melanocytic proliferations with a nodular clinical appearance. Dermoscopically they demonstrate a multicomponent and nonspecific pattern. A typical nonpigmented Spitzoid pattern on dermoscopy (with dotted vessels and white lines) does not exclude atypical Spitz tumors.
  • |*Dermoscopy [MESH]
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Case-Control Studies [MESH]
  • |Diagnosis, Differential [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Nevus, Epithelioid and Spindle Cell/*pathology [MESH]
  • |Retrospective Studies [MESH]
  • |Skin Neoplasms/*pathology [MESH]


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