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10.1099/jgv.0.000261 http://scihub22266oqcxt.onion/10.1099/jgv.0.000261 C4806578!4806578 !26253191     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26253191 &cmd=llinks): Failed to open stream: HTTP request failed! 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Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-? |pdf=|usr=}}{{26253191 }} gab.com Text Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor- JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=26253191 #FOAvip Human respiratory syncytial virus (RSV) is a major health challenge in the young and elderly owing to the lack of a safe and effective vaccine and proven antiviral drugs. Understanding the mechanisms by which viral genes and proteins modulate the host response to infection is critical for identifying novel disease intervention strategies. In this study, the RSV non-structural protein NS1 was shown to suppress miR-24 expression during infection. Lack of NS1 was linked to increased expression of miR-24, whilst NS1 overexpression suppressed miR-24 expression. NS1 was found to induce Kruppel-like factor 6 (KLF6), a transcription factor that positively regulates the transforming growth factor (TGF)-b pathway to induce cell cycle arrest. Silencing of KLF6 led to increased miR-24 expression via downregulation of TGF-?. Treatment with exogenous TGF-? suppressed miR-24 expression and induced KLF6. Confocal microscopy showed co-localization of KLF6 and RSV NS1. These findings indicated that RSV NS1 interacts with KLF6 and modulates miR-24 expression and TGF-?, which facilitates RSV replication. Twit Text FOAVip Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor- ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=26253191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26253191 #FOAvip English Wikipedia <ref>{{Cite pmid|26253191 }}</ref> Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-? #MMPMID26253191 Bakre A ; Wu W ; Hiscox J ; Spann K ; Teng MN ; Tripp RA J Gen Virol 2015[Nov]; 96 (11 ): 3179-3191 PMID26253191 show ga Human respiratory syncytial virus (RSV) is a major health challenge in the young and elderly owing to the lack of a safe and effective vaccine and proven antiviral drugs. Understanding the mechanisms by which viral genes and proteins modulate the host response to infection is critical for identifying novel disease intervention strategies. In this study, the RSV non-structural protein NS1 was shown to suppress miR-24 expression during infection. Lack of NS1 was linked to increased expression of miR-24, whilst NS1 overexpression suppressed miR-24 expression. NS1 was found to induce Kruppel-like factor 6 (KLF6), a transcription factor that positively regulates the transforming growth factor (TGF)-b pathway to induce cell cycle arrest. Silencing of KLF6 led to increased miR-24 expression via downregulation of TGF-?. Treatment with exogenous TGF-? suppressed miR-24 expression and induced KLF6. Confocal microscopy showed co-localization of KLF6 and RSV NS1. These findings indicated that RSV NS1 interacts with KLF6 and modulates miR-24 expression and TGF-?, which facilitates RSV replication. |Host-Pathogen Interactions [MESH] |Humans [MESH] |Kruppel-Like Factor 6 [MESH] |Kruppel-Like Transcription Factors/genetics/metabolism [MESH] |MicroRNAs/*genetics/metabolism [MESH] |Proto-Oncogene Proteins/genetics/metabolism [MESH] |Respiratory Syncytial Virus Infections/*genetics/metabolism/virology [MESH] |Respiratory Syncytial Virus, Human/genetics/*metabolism [MESH] |Transforming Growth Factor beta/*metabolism [MESH]Human respiratory syncytial virus non-structural protein NS1 modifies (epmc).pdf DeepDyve Pubget Overpricing