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10.7150/thno.14555 http://scihub22266oqcxt.onion/10.7150/thno.14555 C4805663!4805663 !27022416     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27022416 &cmd=llinks): Failed to open stream: HTTP request failed! 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A Phosphorus Phthalocyanine Formulation with Intense Absorbance at 1000 nm for Deep Optical Imaging |pdf=|usr=}}{{27022416 }} gab.com Text A Phosphorus Phthalocyanine Formulation with Intense Absorbance at 1000 nm for Deep Optical Imaging JO: Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=27022416 #FOAvip Although photoacoustic computed tomography (PACT) operates with high spatial resolution in biological tissues deeper than other optical modalities, light scattering is a limiting factor. The use of longer near infrared wavelengths reduces scattering. Recently, the rational design of a stable phosphorus phthalocyanine (P-Pc) with a long wavelength absorption band beyond 1000 nm has been reported. Here, we show that when dissolved in liquid surfactants, P-Pc can give rise to formulations with absorbance of greater than 1000 (calculated for a 1 cm path length) at wavelengths beyond 1000 nm. Using the broadly accessible Nd:YAG pulse laser emission output of 1064 nm, P-Pc could be imaged through 11.6 cm of chicken breast with PACT. P-Pc accumulated passively in tumors following intravenous injection in mice as observed by PACT. Following oral administration, P-Pc passed through the intestine harmlessly, and PACT could be used to non-invasively observe intestine function. When the contrast agent placed under the arm of a healthy adult human, a PACT transducer on the top of the arm could readily detect P-Pc through the entire 5 cm limb. Thus, the approach of using contrast media with extreme absorption at 1064 nm readily enables high quality optical imaging in vitro and in vivo in humans at exceptional depths. Twit Text FOAVip A Phosphorus Phthalocyanine Formulation with Intense Absorbance at 1000 nm for Deep Optical Imaging ????Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=27022416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27022416 #FOAvip English Wikipedia <ref>{{Cite pmid|27022416 }}</ref> A Phosphorus Phthalocyanine Formulation with Intense Absorbance at 1000 nm for Deep Optical Imaging #MMPMID27022416 Zhou Y ; Wang D ; Zhang Y ; Chitgupi U ; Geng J ; Wang Y ; Zhang Y ; Cook TR ; Xia J ; Lovell JF Theranostics 2016[]; 6 (5 ): 688-97 PMID27022416 show ga Although photoacoustic computed tomography (PACT) operates with high spatial resolution in biological tissues deeper than other optical modalities, light scattering is a limiting factor. The use of longer near infrared wavelengths reduces scattering. Recently, the rational design of a stable phosphorus phthalocyanine (P-Pc) with a long wavelength absorption band beyond 1000 nm has been reported. Here, we show that when dissolved in liquid surfactants, P-Pc can give rise to formulations with absorbance of greater than 1000 (calculated for a 1 cm path length) at wavelengths beyond 1000 nm. Using the broadly accessible Nd:YAG pulse laser emission output of 1064 nm, P-Pc could be imaged through 11.6 cm of chicken breast with PACT. P-Pc accumulated passively in tumors following intravenous injection in mice as observed by PACT. Following oral administration, P-Pc passed through the intestine harmlessly, and PACT could be used to non-invasively observe intestine function. When the contrast agent placed under the arm of a healthy adult human, a PACT transducer on the top of the arm could readily detect P-Pc through the entire 5 cm limb. Thus, the approach of using contrast media with extreme absorption at 1064 nm readily enables high quality optical imaging in vitro and in vivo in humans at exceptional depths. |Administration, Intravenous [MESH] |Administration, Oral [MESH] |Animals [MESH] |Chemical Phenomena [MESH] |Chickens [MESH] |Humans [MESH] |Indoles/chemistry/*pharmacokinetics [MESH] |Isoindoles [MESH] |Mice [MESH] |Optical Imaging/*methods [MESH] |Phosphorus/chemistry/*pharmacokinetics [MESH] |Photoacoustic Techniques/methods [MESH]A Phosphorus Phthalocyanine Formulation with Intense Absorbance at 100(epmc).pdf DeepDyve Pubget Overpricing