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2016 ; 7
(ä): 89
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Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication
for Allotransplantation
#MMPMID27047489
Degauque N
; Brouard S
; Soulillou JP
Front Immunol
2016[]; 7
(ä): 89
PMID27047489
show ga
Being able to track donor reactive T cells during the course of organ
transplantation is a key to improve the graft survival, to prevent graft
dysfunction, and to adapt the immunosuppressive regimen. The attempts of
transplant immunologists have been for long hampered by the large size of the
alloreactive T cell repertoire. Understanding how self-TCR can interact with
allogeneic MHC is a key to critically appraise the different assays available to
analyze the TCR V? repertoire usage. In this report, we will review conceptually
and experimentally the process of cross-reactivity. We will then highlight what
can be learned from allotransplantation, a situation of artificial
cross-reactivity. Finally, the low- and high-resolution techniques to
characterize the TCR V? repertoire usage in transplantation will be critically
discussed.