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10.3389/fimmu.2016.00089

http://scihub22266oqcxt.onion/10.3389/fimmu.2016.00089
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C4805583!4805583 !27047489
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suck abstract from ncbi


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pmid27047489
      Front+Immunol 2016 ; 7 (ä): 89
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  • Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation #MMPMID27047489
  • Degauque N ; Brouard S ; Soulillou JP
  • Front Immunol 2016[]; 7 (ä): 89 PMID27047489 show ga
  • Being able to track donor reactive T cells during the course of organ transplantation is a key to improve the graft survival, to prevent graft dysfunction, and to adapt the immunosuppressive regimen. The attempts of transplant immunologists have been for long hampered by the large size of the alloreactive T cell repertoire. Understanding how self-TCR can interact with allogeneic MHC is a key to critically appraise the different assays available to analyze the TCR V? repertoire usage. In this report, we will review conceptually and experimentally the process of cross-reactivity. We will then highlight what can be learned from allotransplantation, a situation of artificial cross-reactivity. Finally, the low- and high-resolution techniques to characterize the TCR V? repertoire usage in transplantation will be critically discussed.
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