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10.1007/s00018-016-2145-x http://scihub22266oqcxt.onion/10.1007/s00018-016-2145-x C4805483!4805483!26846695     free     free     free       Cell+Mol+Life+Sci 2016 ; 73 (8): 1645-58 Nephropedia Template TP {{tp|p=26846695|t=2016. The Epigenetic Role of Vitamin C in Health and Disease |pdf=|usr=}}{{26846695}} gab.com Text The Epigenetic Role of Vitamin C in Health and Disease JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=26846695 #FOAvip Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that catalyze histone demethylation. Variation in ascorbate bioavailability thus can influence the demethylation of both DNA and histone, further leading to different phenotypic presentations. Ascorbate deficiency can be presented systematically, spatially and temporally in different tissues at the different stages of development and aging. Here, we review how ascorbate deficiency could potentially be involved in embryonic and postnatal development, and plays a role in various diseases such as neurodegeneration and cancer through epigenetic dysregulation. Twit Text FOAVip The Epigenetic Role of Vitamin C in Health and Disease ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=26846695 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26846695 #FOAvip English Wikipedia <ref>{{Cite pmid|26846695}}</ref> The Epigenetic Role of Vitamin C in Health and Disease #MMPMID26846695 Camarena V; Wang G Cell Mol Life Sci 2016[Apr]; 73 (8): 1645-58 PMID26846695show ga Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that catalyze histone demethylation. Variation in ascorbate bioavailability thus can influence the demethylation of both DNA and histone, further leading to different phenotypic presentations. Ascorbate deficiency can be presented systematically, spatially and temporally in different tissues at the different stages of development and aging. Here, we review how ascorbate deficiency could potentially be involved in embryonic and postnatal development, and plays a role in various diseases such as neurodegeneration and cancer through epigenetic dysregulation. äThe Epigenetic Role of Vitamin C in Health and Disease (epmc).pdf DeepDyve Pubget Overpricing