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10.1016/j.tig.2016.02.001

http://scihub22266oqcxt.onion/10.1016/j.tig.2016.02.001
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C4805481!4805481!26922301
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suck abstract from ncbi


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pmid26922301      Trends+Genet 2016 ; 32 (4): 211-24
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  • The emerging function and mechanism of ceRNAs in cancer #MMPMID26922301
  • Wang Y; Hou J; He D; Sun M; Zhang P; Yu Y; Chen Y
  • Trends Genet 2016[Apr]; 32 (4): 211-24 PMID26922301show ga
  • Complex diseases such as cancer are often associated with aberrant gene expression at both the transcriptional and post-transcriptional level. In the past several years, competing endogenous RNAs (ceRNAs) have emerged as an important class of post-transcriptional regulators that alter gene expression through a microRNA-mediated mechanism. Recent studies in both solid tumors and hematopoietic malignancies showed that ceRNAs play significant roles in cancer pathogenesis by altering the expression of key tumorigenic or tumor suppressive genes. Characterizing the identity, function and mechanism of the ceRNAs will not only further our fundamental understanding of RNA-mediated cancer pathogenesis, but also may shed light on developing new RNA-based therapeutic strategies for treating cancer.
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