Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/jacs.5b12608 http://scihub22266oqcxt.onion/10.1021/jacs.5b12608 C4805449!4805449!26907082     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2016 ; 138 (11): 3610-22 Nephropedia Template TP {{tp|p=26907082|t=2016. On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry |pdf=|usr=}}{{26907082}} gab.com Text On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=26907082 #FOAvip Proximity enhancement is a central chemical tenet underpinning an exciting suite of small-molecule toolsets that have allowed us to unravel many biological complexities. The leitmotif of this opus is ?tethering??a strategy in which a multifunctional small molecule serves as a template to bring proteins/biomolecules together. Scaffolding approaches have been powerfully applied to control diverse biological outcomes such as protein?protein association, protein stability, activity, and improve imaging capabilities. A new twist on this strategy has recently appeared, in which the small-molecule probe is engineered to unleash controlled amounts of reactive chemical signals within the microenvironment of a target protein. Modification of a specific target elicits a precisely timed and spatially controlled gain-of-function (or dominant loss-of-function) signaling response. Presented herein is a unique personal outlook conceptualizing the powerful proximity-enhanced chemical biology toolsets into two paradigms: ?multifunctional scaffolding? versus ?on-demand targeting?. By addressing the latest advances and challenges in the established yet constantly evolving multifunctional scaffolding strategies as well as in the emerging on-demand precision targeting (and related) systems, this Perspective is aimed at choosing when it is best to employ each of the two strategies, with an emphasis toward further promoting novel applications and discoveries stemming from these innovative chemical biology platforms. Twit Text FOAVip On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=26907082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26907082 #FOAvip English Wikipedia <ref>{{Cite pmid|26907082}}</ref> On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry #MMPMID26907082 Long MC; Poganik JR; Aye Y J Am Chem Soc 2016[Mar]; 138 (11): 3610-22 PMID26907082show ga Proximity enhancement is a central chemical tenet underpinning an exciting suite of small-molecule toolsets that have allowed us to unravel many biological complexities. The leitmotif of this opus is ?tethering??a strategy in which a multifunctional small molecule serves as a template to bring proteins/biomolecules together. Scaffolding approaches have been powerfully applied to control diverse biological outcomes such as protein?protein association, protein stability, activity, and improve imaging capabilities. A new twist on this strategy has recently appeared, in which the small-molecule probe is engineered to unleash controlled amounts of reactive chemical signals within the microenvironment of a target protein. Modification of a specific target elicits a precisely timed and spatially controlled gain-of-function (or dominant loss-of-function) signaling response. Presented herein is a unique personal outlook conceptualizing the powerful proximity-enhanced chemical biology toolsets into two paradigms: ?multifunctional scaffolding? versus ?on-demand targeting?. By addressing the latest advances and challenges in the established yet constantly evolving multifunctional scaffolding strategies as well as in the emerging on-demand precision targeting (and related) systems, this Perspective is aimed at choosing when it is best to employ each of the two strategies, with an emphasis toward further promoting novel applications and discoveries stemming from these innovative chemical biology platforms. äOn-Demand Targeting: Investigating Biology with Proximity-Directed Che(epmc).pdf DeepDyve Pubget Overpricing