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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Opin+Behav+Sci 2016 ; 7 (ä): 69-75 Nephropedia Template TP
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Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints #MMPMID27019862
Palanza P; Nagel SC; Parmigiani S; vom Saal FS
Curr Opin Behav Sci 2016[Feb]; 7 (ä): 69-75 PMID27019862show ga
Of the approximately 85,000 chemicals in use, 1000 have been identified as having the ability to disrupt normal endocrine function. Exposure to endocrine disrupting chemicals (EDCs) during critical period in brain differentiation (prenatal and neonatal life) via the mother can alter the course of the development of sexually dimorphic behaviors. Bisphenol A (BPA) is a very high volume chemical used in plastic, resins and other products, and virtually everyone examined has detectable BPA. BPA has estrogenic activity and is one of the most studied EDCs. We review evidence from studies in rodents using dose levels relevant to human exposure. BPA alters behavior and eliminates or in some cases reverses sexually dimorphic behaviors observed in unexposed animals.