Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3892/mmr.2016.4986 http://scihub22266oqcxt.onion/10.3892/mmr.2016.4986 C4805073!4805073 !26956539     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26956539 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26956539 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2016 ; 13 (4 ): 3466-74 Nephropedia Template TP {{tp|p=26956539 |t=2016. Constitutive expression of Wnt/??catenin target genes promotes proliferation and invasion of liver cancer stem cells |pdf=|usr=}}{{26956539 }} gab.com Text Constitutive expression of Wnt/ catenin target genes promotes proliferation and invasion of liver cancer stem cells JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26956539 #FOAvip Wnt/??catenin is an important signaling pathways involved in the tumorgenesis, progression and maintenance of cancer stem cells (CSCs). In the present study, the role of Wnt/??catenin signaling in CSC?mediated tumorigenesis and invasion in liver CSCs was investigated. A small population of cancer stem?like side population (SP) cells (3.6%) from liver cancer samples were identified. The cells were highly resistant to drug treatment due to the enhanced expression of drug efflux pumps, such as ABC subfamily G member 2, multidrug resistance protein 1 and ATP?binding cassette subfamily B member 5. Furthermore, using TOPflash and reverse transcription?quantitative polymerase chain reaction analysis, Wnt/??catenin signaling and the transcriptional regulation of Wnt/??catenin target genes including dickkopf Wnt signaling pathway inhibitor 1, axis inhibition protein 2 and cyclin D1 were observed to be markedly upregulated in liver cancer SP cells. As a consequence, SP cells possessed infinite cell proliferation potential and the ability to generating tumor spheres. In addition, upon reducing Wnt/??catenin signaling, the rates of proliferation, tumor sphere formation and tumor invasion of SP cells were markedly reduced. Therefore, these data suggest that Wnt/??catenin signaling is a potential therapeutic target to reduce CSC?mediated tumorigenicity and invasion in liver cancer. Twit Text FOAVip Constitutive expression of Wnt/ catenin target genes promotes proliferation and invasion of liver cancer stem cells ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26956539 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26956539 #FOAvip English Wikipedia <ref>{{Cite pmid|26956539 }}</ref> Constitutive expression of Wnt/??catenin target genes promotes proliferation and invasion of liver cancer stem cells #MMPMID26956539 Chen W ; Zhang YW ; Li Y ; Zhang JW ; Zhang T ; Fu BS ; Zhang Q ; Jiang N Mol Med Rep 2016[Apr]; 13 (4 ): 3466-74 PMID26956539 show ga Wnt/??catenin is an important signaling pathways involved in the tumorgenesis, progression and maintenance of cancer stem cells (CSCs). In the present study, the role of Wnt/??catenin signaling in CSC?mediated tumorigenesis and invasion in liver CSCs was investigated. A small population of cancer stem?like side population (SP) cells (3.6%) from liver cancer samples were identified. The cells were highly resistant to drug treatment due to the enhanced expression of drug efflux pumps, such as ABC subfamily G member 2, multidrug resistance protein 1 and ATP?binding cassette subfamily B member 5. Furthermore, using TOPflash and reverse transcription?quantitative polymerase chain reaction analysis, Wnt/??catenin signaling and the transcriptional regulation of Wnt/??catenin target genes including dickkopf Wnt signaling pathway inhibitor 1, axis inhibition protein 2 and cyclin D1 were observed to be markedly upregulated in liver cancer SP cells. As a consequence, SP cells possessed infinite cell proliferation potential and the ability to generating tumor spheres. In addition, upon reducing Wnt/??catenin signaling, the rates of proliferation, tumor sphere formation and tumor invasion of SP cells were markedly reduced. Therefore, these data suggest that Wnt/??catenin signaling is a potential therapeutic target to reduce CSC?mediated tumorigenicity and invasion in liver cancer. |ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism [MESH] |Animals [MESH] |Antineoplastic Agents/therapeutic use [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Cyclin D1/genetics/metabolism [MESH] |Female [MESH] |Humans [MESH] |Liver Neoplasms/drug therapy/metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Middle Aged [MESH] |Neoplastic Stem Cells/cytology/*metabolism [MESH] |Side-Population Cells/cytology/metabolism [MESH] |Tumor Cells, Cultured [MESH] |Up-Regulation [MESH] |Wnt Proteins/*metabolism [MESH] |Wnt Signaling Pathway [MESH]Constitutive expression of Wnt/??catenin target genes promotes prolife(epmc).pdf DeepDyve Pubget Overpricing