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10.1038/nrcardio.2015.161 http://scihub22266oqcxt.onion/10.1038/nrcardio.2015.161 C4804623!4804623!26483167     free     free     free       Nat+Rev+Cardiol 2015 ; 12 (12): 689-710 Nephropedia Template TP {{tp|p=26483167|t=2015. Mitral valve disease?morphology and mechanisms |pdf=|usr=}}{{26483167}} gab.com Text Mitral valve disease morphology and mechanisms JO: Nat Rev Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26483167 #FOAvip Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence indicates that the mitral valve is not a passive structure, but?even in adult life?remains dynamic and accessible for treatment. This concept motivates efforts to reduce the clinical progression of mitral valve disease through early detection and modification of underlying mechanisms. Discoveries of genetic mutations causing mitral valve elongation and prolapse have revealed that growth factor signalling and cell migration pathways are regulated by structural molecules in ways that can be modified to limit progression from developmental defects to valve degeneration with clinical complications. Mitral valve enlargement can determine left ventricular outflow tract obstruction in hypertrophic cardiomyopathy, and might be stimulated by potentially modifiable biological valvular?ventricular interactions. Mitral valve plasticity also allows adaptive growth in response to ventricular remodelling. However, adverse cellular and mechanobiological processes create relative leaflet deficiency in the ischaemic setting, leading to mitral regurgitation with increased heart failure and mortality. Our approach, which bridges clinicians and basic scientists, enables the correlation of observed disease with cellular and molecular mechanisms, leading to the discovery of new opportunities for improving the natural history of mitral valve disease. Twit Text FOAVip Mitral valve disease morphology and mechanisms ????Nat Rev Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26483167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26483167 #FOAvip English Wikipedia <ref>{{Cite pmid|26483167}}</ref> Mitral valve disease?morphology and mechanisms #MMPMID26483167 Levine RA; Hagége AA; Judge DP; Padala M; Dal-Bianco JP; Aikawa E; Beaudoin J; Bischoff J; Bouatia-Naji N; Bruneval P; Butcher JT; Carpentier A; Chaput M; Chester AH; Clusel C; Delling FN; Dietz HC; Dina C; Durst R; Fernandez-Friera L; Handschumacher MD; Jensen MO; Jeunemaitre XP; Le Marec H; Le Tourneau T; Markwald RR; Mérot J; Messas E; Milan DP; Neri T; Norris RA; Peal D; Perrocheau M; Probst V; Pucéat M; Rosenthal N; Solis J; Schott JJ; Schwammenthal E; Slaugenhaupt SA; Song JK; Yacoub MH Nat Rev Cardiol 2015[Dec]; 12 (12): 689-710 PMID26483167show ga Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence indicates that the mitral valve is not a passive structure, but?even in adult life?remains dynamic and accessible for treatment. This concept motivates efforts to reduce the clinical progression of mitral valve disease through early detection and modification of underlying mechanisms. Discoveries of genetic mutations causing mitral valve elongation and prolapse have revealed that growth factor signalling and cell migration pathways are regulated by structural molecules in ways that can be modified to limit progression from developmental defects to valve degeneration with clinical complications. Mitral valve enlargement can determine left ventricular outflow tract obstruction in hypertrophic cardiomyopathy, and might be stimulated by potentially modifiable biological valvular?ventricular interactions. Mitral valve plasticity also allows adaptive growth in response to ventricular remodelling. However, adverse cellular and mechanobiological processes create relative leaflet deficiency in the ischaemic setting, leading to mitral regurgitation with increased heart failure and mortality. Our approach, which bridges clinicians and basic scientists, enables the correlation of observed disease with cellular and molecular mechanisms, leading to the discovery of new opportunities for improving the natural history of mitral valve disease. äMitral valve disease?morphology and mechanisms (epmc).pdf DeepDyve Pubget Overpricing