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10.1002/prp2.220 http://scihub22266oqcxt.onion/10.1002/prp2.220 C4804326!4804326!27069631     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27069631.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pharmacol+Res+Perspect 2016 ; 4 (2): ä Nephropedia Template TP {{tp|p=27069631|t=2016. Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome |pdf=|usr=}}{{27069631}} gab.com Text Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome JO: Pharmacol Res Perspect http://www.kidney.de/pget.php?&tw=1&pmid=27069631 #FOAvip Cannabidiol (CBD) reduces seizures in childhood epilepsy syndromes including Dravet syndrome (DS). A formulation of CBD has obtained orphan drug designation for these syndromes and clinical trials are currently underway. The mechanism responsible for CBD effects is not known, although it could involve targets sensitive to CBD in other neurological disorders. We believe of interest to investigate whether these potential targets are altered in DS, in particular whether the endocannabinoid system is dysregulated. To this end, lymphocytes from patients and controls were used for analysis of gene expression of transmitter receptors and transporters, ion channels, and enzymes associated with CBD effects, as well as endocannabinoid genes. Plasma endocannabinoid levels were also analyzed. There were no differences between DS patients and controls in most of the CBD targets analyzed, except an increase in the voltage?dependent calcium channel ??1h subunit. We also found that cannabinoid type?2 (CB2) receptor gene expression was elevated in DS patients, with no changes in other endocannabinoid?related receptors and enzymes, as well as in plasma levels of endocannabinoids. Such elevation was paralleled by an increase in CD70, a marker of lymphocyte activation, and certain trends in inflammation?related proteins (e.g., peroxisome proliferator?activated receptor?? receptors, cytokines). In conclusion, together with changes in the voltage?dependent calcium channel ??1h subunit, we found an upregulation of CB2 receptors, associated with an activation of lymphocytes and changes in inflammation?related genes, in DS patients. Such changes were also reported in inflammatory disorders and may indirectly support the occurrence of a potential dysregulation of the endocannabinoid system in the brain. Twit Text FOAVip Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome ????Pharmacol Res Perspect http://www.kidney.de/pget.php?&tw=1&pmid=27069631 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27069631 #FOAvip English Wikipedia <ref>{{Cite pmid|27069631}}</ref> Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome #MMPMID27069631 Rubio M; Valdeolivas S; Piscitelli F; Verde R; Satta V; Barroso E; Montolio M; Aras LM; Di Marzo V; Sagredo O; Fernández?Ruiz J Pharmacol Res Perspect 2016[Apr]; 4 (2): ä PMID27069631show ga Cannabidiol (CBD) reduces seizures in childhood epilepsy syndromes including Dravet syndrome (DS). A formulation of CBD has obtained orphan drug designation for these syndromes and clinical trials are currently underway. The mechanism responsible for CBD effects is not known, although it could involve targets sensitive to CBD in other neurological disorders. We believe of interest to investigate whether these potential targets are altered in DS, in particular whether the endocannabinoid system is dysregulated. To this end, lymphocytes from patients and controls were used for analysis of gene expression of transmitter receptors and transporters, ion channels, and enzymes associated with CBD effects, as well as endocannabinoid genes. Plasma endocannabinoid levels were also analyzed. There were no differences between DS patients and controls in most of the CBD targets analyzed, except an increase in the voltage?dependent calcium channel ??1h subunit. We also found that cannabinoid type?2 (CB2) receptor gene expression was elevated in DS patients, with no changes in other endocannabinoid?related receptors and enzymes, as well as in plasma levels of endocannabinoids. Such elevation was paralleled by an increase in CD70, a marker of lymphocyte activation, and certain trends in inflammation?related proteins (e.g., peroxisome proliferator?activated receptor?? receptors, cytokines). In conclusion, together with changes in the voltage?dependent calcium channel ??1h subunit, we found an upregulation of CB2 receptors, associated with an activation of lymphocytes and changes in inflammation?related genes, in DS patients. Such changes were also reported in inflammatory disorders and may indirectly support the occurrence of a potential dysregulation of the endocannabinoid system in the brain. äAnalysis of endocannabinoid signaling elements and related proteins in(epmc).pdf DeepDyve Pubget Overpricing