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10.1038/ncomms11103 http://scihub22266oqcxt.onion/10.1038/ncomms11103 C4804176!4804176!27002738     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27002738|t=2016. Genetic link between renal birth defects and congenital heart disease |pdf=|usr=}}{{27002738}} gab.com Text Genetic link between renal birth defects and congenital heart disease JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27002738 #FOAvip Structural birth defects in the kidney and urinary tract are observed in 0.5% of live births and are a major cause of end-stage renal disease, but their genetic aetiology is not well understood. Here we analyse 135 lines of mice identified in large-scale mouse mutagenesis screen and show that 29% of mutations causing congenital heart disease (CHD) also cause renal anomalies. The renal anomalies included duplex and multiplex kidneys, renal agenesis, hydronephrosis and cystic kidney disease. To assess the clinical relevance of these findings, we examined patients with CHD and observed a 30% co-occurrence of renal anomalies of a similar spectrum. Together, these findings demonstrate a common shared genetic aetiology for CHD and renal anomalies, indicating that CHD patients are at increased risk for complications from renal anomalies. This collection of mutant mouse models provides a resource for further studies to elucidate the developmental link between renal anomalies and CHD. Twit Text FOAVip Genetic link between renal birth defects and congenital heart disease ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27002738 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27002738 #FOAvip English Wikipedia <ref>{{Cite pmid|27002738}}</ref> Genetic link between renal birth defects and congenital heart disease #MMPMID27002738 San Agustin JT; Klena N; Granath K; Panigrahy A; Stewart E; Devine W; Strittmatter L; Jonassen JA; Liu X; Lo CW; Pazour GJ Nat Commun 2016[]; 7 (ä): ä PMID27002738show ga Structural birth defects in the kidney and urinary tract are observed in 0.5% of live births and are a major cause of end-stage renal disease, but their genetic aetiology is not well understood. Here we analyse 135 lines of mice identified in large-scale mouse mutagenesis screen and show that 29% of mutations causing congenital heart disease (CHD) also cause renal anomalies. The renal anomalies included duplex and multiplex kidneys, renal agenesis, hydronephrosis and cystic kidney disease. To assess the clinical relevance of these findings, we examined patients with CHD and observed a 30% co-occurrence of renal anomalies of a similar spectrum. Together, these findings demonstrate a common shared genetic aetiology for CHD and renal anomalies, indicating that CHD patients are at increased risk for complications from renal anomalies. This collection of mutant mouse models provides a resource for further studies to elucidate the developmental link between renal anomalies and CHD. äGenetic link between renal birth defects and congenital heart disease (epmc).pdf DeepDyve Pubget Overpricing