Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium
Thiopental Versus Propofol
#MMPMID26383207
Jarineshin H
; Kashani S
; Fekrat F
; Vatankhah M
; Golmirzaei J
; Alimolaee E
; Zafarpour H
Glob J Health Sci
2015[Jun]; 8
(2
): 126-31
PMID26383207
show ga
INTRODUCTION: General anesthesia is required for Electroconvulsive Therapy (ECT)
and it is usually provided by a hypnotic agent. The seizure duration is important
for the treatment, and it is usually accompanied by severe hemodynamic changes.
The aim of this study was to compare the effects of sodium thiopental versus
Propofol on seizure duration and hemodynamic variables during ECT. METHODS: A
number of 100 patient-sessions of ECT were included in this randomized clinical
trial. The initial hemodynamic state of each patient was recorded. Anesthesia was
induced by Sodium thiopental in the 1st group and with Propofol in 2nd group. All
the patients received the muscle relaxant succinylcholine. The hemodynamic
variables after seizure and seizure duration were recorded. The data were
analyzed through SPSS 20 and independent t-test. P<0.05 was considered
significant. RESULTS: The mean duration of seizure in the sodium thiopental group
was significantly longer than the Propofol group (40.3±16.6 sec versus 32±11.3
sec) (P=0.001). There was no statistically significant difference between the
mean energy level applied in the two groups (20.5±3.81 joules in the sodium
thiopental versus 20.2±3.49 joules in the Propofol group). The mean systolic and
diastolic blood pressure at all times after seizure and mean heart rate at 3 and
5 minutes after seizure were significantly lower in Propofol than sodium
thiopental groups. DISCUSSION AND CONCLUSION: Propofol provides a more stable
hemodynamic state for the ECT procedures, and its use is highly preferred over
sodium thiopental in patients with cardiovascular disease.
|*Electroconvulsive Therapy
[MESH]
|Adolescent
[MESH]
|Adult
[MESH]
|Double-Blind Method
[MESH]
|Female
[MESH]
|Hemodynamics/drug effects
[MESH]
|Humans
[MESH]
|Hypnotics and Sedatives/*administration & dosage
[MESH]
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