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10.5539/gjhs.v7n5p359

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suck abstract from ncbi


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pmid26156901
      Glob+J+Health+Sci 2015 ; 7 (5 ): 359-63
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  • Comparison of Quetiapine and Risperidone in Treatment of Acute Psychosis: A Double-Blind, Randomized-Controlled Study #MMPMID26156901
  • Moosavi SM ; Ahmadi M ; Mojtahedi D ; Yazdani J ; Monajemi MB
  • Glob J Health Sci 2015[Jun]; 7 (5 ): 359-63 PMID26156901 show ga
  • OBJECTIVE: The aim of this study was to evaluate the effectiveness of Quetiapine versus Risperidone in control of acute psychotic signs and symptoms in hospitalized patients during four weeks. METHODS: In this double-blind, randomized controlled study, a total of 90 patients with a confirmed diagnosis acute psychosis and were hospitalized in Zare Hospital, Sari, Iran, and they were treated with Quetiapine (mean 500 mg/day) or Risperidone (mean 5.2 mg/day), in a 4 week period. The positive and negative symptoms scale (PANSS) and Clinical Global Impression-Severity scale (CGI-s) were used to assess psychotic symptoms and severity of illness in first and the last day of the study. RESULTS: No significant difference found between two groups in decreasing positive and negative sub-scores in the PANSS. Risperidone was superior to Quetiapine in decreasing the PANSS general psychopathology sub-scores and total score (p<0.05). No significant difference found between two groups in decreasing CGI-s score.
  • |Acute Disease [MESH]
  • |Adult [MESH]
  • |Antipsychotic Agents/*administration & dosage [MESH]
  • |Dibenzothiazepines/*administration & dosage [MESH]
  • |Double-Blind Method [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Outcome Assessment, Health Care [MESH]
  • |Psychotic Disorders/*drug therapy [MESH]
  • |Quetiapine Fumarate [MESH]
  • |Risperidone/*administration & dosage [MESH]
  • |Severity of Illness Index [MESH]


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