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2015 ; 7
(5
): 359-63
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Comparison of Quetiapine and Risperidone in Treatment of Acute Psychosis: A
Double-Blind, Randomized-Controlled Study
#MMPMID26156901
Moosavi SM
; Ahmadi M
; Mojtahedi D
; Yazdani J
; Monajemi MB
Glob J Health Sci
2015[Jun]; 7
(5
): 359-63
PMID26156901
show ga
OBJECTIVE: The aim of this study was to evaluate the effectiveness of Quetiapine
versus Risperidone in control of acute psychotic signs and symptoms in
hospitalized patients during four weeks. METHODS: In this double-blind,
randomized controlled study, a total of 90 patients with a confirmed diagnosis
acute psychosis and were hospitalized in Zare Hospital, Sari, Iran, and they were
treated with Quetiapine (mean 500 mg/day) or Risperidone (mean 5.2 mg/day), in a
4 week period. The positive and negative symptoms scale (PANSS) and Clinical
Global Impression-Severity scale (CGI-s) were used to assess psychotic symptoms
and severity of illness in first and the last day of the study. RESULTS: No
significant difference found between two groups in decreasing positive and
negative sub-scores in the PANSS. Risperidone was superior to Quetiapine in
decreasing the PANSS general psychopathology sub-scores and total score (p<0.05).
No significant difference found between two groups in decreasing CGI-s score.