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10.1016/j.redox.2015.01.003

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suck abstract from ncbi


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pmid25618581
      Redox+Biol 2015 ; 4 (ä): 242-59
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  • Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches #MMPMID25618581
  • Zhang J
  • Redox Biol 2015[]; 4 (ä): 242-59 PMID25618581 show ga
  • Autophagy is a lysosomal mediated degradation activity providing an essential mechanism for recycling cellular constituents, and clearance of excess or damaged lipids, proteins and organelles. Autophagy involves more than 30 proteins and is regulated by nutrient availability, and various stress sensing signaling pathways. This article provides an overview of the mechanisms and regulation of autophagy, its role in health and diseases, and methods for its measurement. Hopefully this teaching review together with the graphic illustrations will be helpful for instructors teaching graduate students who are interested in grasping the concepts and major research areas and introducing recent developments in the field.
  • |*Autophagy [MESH]
  • |*Mitophagy [MESH]
  • |Aging/genetics/*metabolism [MESH]
  • |Apoptosis Regulatory Proteins/genetics/metabolism [MESH]
  • |Beclin-1 [MESH]
  • |Communicable Diseases/genetics/*metabolism/pathology [MESH]
  • |Gene Expression Regulation [MESH]
  • |Humans [MESH]
  • |Membrane Proteins/genetics/metabolism [MESH]
  • |Microtubule-Associated Proteins/genetics/metabolism [MESH]
  • |Mitochondria/*metabolism/pathology [MESH]
  • |Molecular Biology/instrumentation/methods [MESH]
  • |Neoplasms/genetics/*metabolism/pathology [MESH]
  • |Neurodegenerative Diseases/genetics/*metabolism/pathology [MESH]
  • |Oxidation-Reduction [MESH]
  • |Oxidative Stress [MESH]
  • |Signal Transduction [MESH]


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