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10.1038/onc.2015.176 http://scihub22266oqcxt.onion/10.1038/onc.2015.176 C4803473!4803473!26073083     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26073083&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Oncogene 2016 ; 35 (9): 1180-92 Nephropedia Template TP {{tp|p=26073083|t=2016. A microRNA code for prostate cancer metastasis |pdf=|usr=}}{{26073083}} gab.com Text A microRNA code for prostate cancer metastasis JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26073083 #FOAvip Although the development of bone metastasis is a major detrimental event in prostate cancer, the molecular mechanisms responsible for bone homing and destruction remain largely unknown. Here we show that loss of miR-15 and miR-16 in cooperation with increased miR-21 expression promote prostate cancer spreading and bone lesions. This combination of microRNA endows bone-metastatic potential to prostate cancer cells. Concomitant loss of miR-15/miR-16 and gain of miR-21 aberrantly activate TGF-? and Hedgehog signaling, that mediate local invasion, distant bone marrow colonization and osteolysis by prostate cancer cells. These findings establish a new molecular circuitry for prostate cancer metastasis that was validated in patients' cohorts. Our data indicate a network of biomarkers and druggable pathways to improve patient treatment. Twit Text FOAVip A microRNA code for prostate cancer metastasis ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26073083 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26073083 #FOAvip English Wikipedia <ref>{{Cite pmid|26073083}}</ref> A microRNA code for prostate cancer metastasis #MMPMID26073083 Bonci D; Coppola V; Patrizii M; Addario A; Cannistraci A; Francescangeli F; Pecci R; Muto G; Collura D; Bedini R; Zeuner A; Valtieri M; Sentinelli S; Benassi MS; Gallucci M; Carlini P; Piccolo S; De Maria R Oncogene 2016[Mar]; 35 (9): 1180-92 PMID26073083show ga Although the development of bone metastasis is a major detrimental event in prostate cancer, the molecular mechanisms responsible for bone homing and destruction remain largely unknown. Here we show that loss of miR-15 and miR-16 in cooperation with increased miR-21 expression promote prostate cancer spreading and bone lesions. This combination of microRNA endows bone-metastatic potential to prostate cancer cells. Concomitant loss of miR-15/miR-16 and gain of miR-21 aberrantly activate TGF-? and Hedgehog signaling, that mediate local invasion, distant bone marrow colonization and osteolysis by prostate cancer cells. These findings establish a new molecular circuitry for prostate cancer metastasis that was validated in patients' cohorts. Our data indicate a network of biomarkers and druggable pathways to improve patient treatment. äA microRNA code for prostate cancer metastasis (epmc).pdf DeepDyve Pubget Overpricing