Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27006441
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Ultrafiltration Failure and Impaired Sodium Sieving During Long-Term Peritoneal
Dialysis: More Than Aquaporin Dysfunction?
#MMPMID27006441
Morelle J
; Sow A
; Hautem N
; Devuyst O
; Goffin E
Perit Dial Int
2016[Mar]; 36
(2
): 227-31
PMID27006441
show ga
Fifteen years ago, our group reported the case of a 67-year-old man on peritoneal
dialysis for 11 years, in whom ultrafiltration failure and impaired sodium
sieving were associated with an apparently normal expression of aquaporin-1
(AQP1) water channels in peritoneal capillaries. At that time, AQP1 dysfunction
was suggested as the cause of impaired free-water transport. However, recent data
from computer simulations, and structural and functional analysis of the
peritoneal membrane of patients with encapsulating peritoneal sclerosis,
demonstrated that changes in the peritoneal interstitium directly alter osmotic
water transport. In light of these insights, we challenge the initial hypothesis
and provide several lines of evidence supporting the diagnosis of encapsulating
peritoneal sclerosis in this patient and suggesting that severe peritoneal
fibrosis accounted for the loss of osmotic conductance developed during the
course of peritoneal dialysis.
free
free
free
