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2016 ; 36
(2
): 140-5
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Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis
Patients: A Randomized Controlled Trial
#MMPMID26475844
Tabibi H
; Imani H
; Atabak S
; Najafi I
; Hedayati M
; Rahmani L
Perit Dial Int
2016[Mar]; 36
(2
): 140-5
PMID26475844
show ga
? BACKGROUND: In peritoneal dialysis (PD) patients, one of the major risk factors
for cardiovascular disease is lipid abnormalities. This study was designed to
investigate the effects of ginger supplementation on serum lipids and
lipoproteins in PD patients. ? METHODS: In this randomized, double-blind,
placebo-controlled trial, 36 PD patients were randomly assigned to either the
ginger or the placebo group. The patients in the ginger group received 1,000 mg
ginger daily for 10 weeks, while the placebo group received corresponding
placebos. At baseline and at the end of week 10, 7 mL of blood were obtained from
each patient after a 12- to 14-hour fast, and serum concentrations of
triglyceride, total cholesterol, low density lipoprotein-cholesterol (LDL-C),
high density lipoprotein-cholesterol (HDL-C), and lipoprotein (a) [Lp (a)] were
measured. ? RESULTS: Serum triglyceride concentration decreased significantly up
to 15% in the ginger group at the end of week 10 compared with baseline (p <
0.01), and the reduction was significant in comparison with the placebo group (p
< 0.05). There were no significant differences between the 2 groups in mean
changes of serum total cholesterol, LDL-C, HDL-C, and Lp (a). ? CONCLUSION: This
study indicates that daily administration of 1,000 mg ginger reduces serum
triglyceride concentration, which is a risk factor for cardiovascular disease, in
PD patients.