Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1210/jc.2015-2860 http://scihub22266oqcxt.onion/10.1210/jc.2015-2860 C4803182!4803182!26713822     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26713822&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Endocrinol+Metab 2016 ; 101 (3): 1044-54 Nephropedia Template TP {{tp|p=26713822|t=2016. Evidence of ?-Cell Dedifferentiation in Human Type 2 Diabetes |pdf=|usr=}}{{26713822}} gab.com Text Evidence of -Cell Dedifferentiation in Human Type 2 Diabetes JO: J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=26713822 #FOAvip Context:: Diabetes is associated with a deficit of insulin-producing ?-cells. Animal studies show that ?-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage, and partly converting to other endocrine cell types. Objective:: To determine whether similar processes occur in human type 2 diabetes, we surveyed pancreatic islets from 15 diabetic and 15 nondiabetic organ donors. Design:: We scored dedifferentiation using markers of endocrine lineage, ?-cell-specific transcription factors, and a newly identified endocrine progenitor cell marker, aldehyde dehydrogenase 1A3. Results:: By these criteria, dedifferentiated cells accounted for 31.9% of ?-cells in type 2 diabetics vs 8.7% in controls, and for 16.8% vs 6.5% of all endocrine cells (P < .001). The number of aldehyde dehydrogenase 1A3-positive/hormone-negative cells was 3-fold higher in diabetics compared with controls. Moreover, ?-cell-specific transcription factors were ectopically found in glucagon- and somatostatin-producing cells of diabetic subjects. Conclusions:: The data support the view that pancreatic ?-cells become dedifferentiated and convert to ?- and ?-?like? cells in human type 2 diabetes. The findings should prompt a reassessment of goals in the prevention and treatment of ?-cell dysfunction. Twit Text FOAVip Evidence of -Cell Dedifferentiation in Human Type 2 Diabetes ????J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=26713822 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26713822 #FOAvip English Wikipedia <ref>{{Cite pmid|26713822}}</ref> Evidence of ?-Cell Dedifferentiation in Human Type 2 Diabetes #MMPMID26713822 Cinti F; Bouchi R; Kim-Muller JY; Ohmura Y; Sandoval PR; Masini M; Marselli L; Suleiman M; Ratner LE; Marchetti P; Accili D J Clin Endocrinol Metab 2016[Mar]; 101 (3): 1044-54 PMID26713822show ga Context:: Diabetes is associated with a deficit of insulin-producing ?-cells. Animal studies show that ?-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage, and partly converting to other endocrine cell types. Objective:: To determine whether similar processes occur in human type 2 diabetes, we surveyed pancreatic islets from 15 diabetic and 15 nondiabetic organ donors. Design:: We scored dedifferentiation using markers of endocrine lineage, ?-cell-specific transcription factors, and a newly identified endocrine progenitor cell marker, aldehyde dehydrogenase 1A3. Results:: By these criteria, dedifferentiated cells accounted for 31.9% of ?-cells in type 2 diabetics vs 8.7% in controls, and for 16.8% vs 6.5% of all endocrine cells (P < .001). The number of aldehyde dehydrogenase 1A3-positive/hormone-negative cells was 3-fold higher in diabetics compared with controls. Moreover, ?-cell-specific transcription factors were ectopically found in glucagon- and somatostatin-producing cells of diabetic subjects. Conclusions:: The data support the view that pancreatic ?-cells become dedifferentiated and convert to ?- and ?-?like? cells in human type 2 diabetes. The findings should prompt a reassessment of goals in the prevention and treatment of ?-cell dysfunction. äEvidence of ?-Cell Dedifferentiation in Human Type 2 Diabetes (epmc).pdf DeepDyve Pubget Overpricing