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10.1053/j.gastro.2009.02.060 http://scihub22266oqcxt.onion/10.1053/j.gastro.2009.02.060 C4802971!4802971!19268670     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gastroenterology 2009 ; 136 (7): 2226-36 Nephropedia Template TP {{tp|p=19268670|t=2009. Heterogeneities in ICC Ca2+ activity within canine large intestine |pdf=|usr=}}{{19268670}} gab.com Text Heterogeneities in ICC Ca2+ activity within canine large intestine JO: Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=19268670 #FOAvip Background & Aims: In human and canine colon, both slow (slow waves, 2?8/min) and fast (myenteric potential oscillations; MPOs, 16?20/min) electrical rhythms in the smooth muscle originate at the submucosal and myenteric borders, respectively. We used Ca2+ imaging to investigate whether ICC at these borders generated distinct rhythms. Methods: Segments of canine colon were pinned submucosal or myenteric surface uppermost, or cut in cross-section. Tissues were loaded with a Ca2+ indicator (fluo-4) and activity was monitored at 36.5±0.5°C using a CCD camera. Results: Rhythmic, biphasic Ca2+ transients (5?8/min), similar in waveform to electrical slow waves, propagated without decrement as a wave front through the ICC-SM network (2?5mm/s), decaying exponentially through the thickness of the CM. In contrast, rhythmic intracellular Ca2+ waves (~16/min) and spontaneous reductions in Ca2+ were observed in ICC-MY. Normally, intracellular Ca2+ waves were unsynchronized between adjacent ICC-MY, although excitatory nerve activity synchronized activity. In addition, spontaneous reductions in Ca2+ were observed that inhibited Ca2+ waves. L-NA (100µM; NO antagonist) blocked the reductions in Ca2+ and increased the frequency (~19/min) of intracellular Ca2+ waves within ICC-MY. Conclusions: ICC-SM form a tightly coupled network that is able to generate and propagate slow waves. In contrast, Ca2+ transients in ICC-MY, which are normally not synchronized, have a similar duration and frequency as MPOs. Like MPOs, their activity is inhibited by nitrergic nerves and synchronized by excitatory nerves. Twit Text FOAVip Heterogeneities in ICC Ca2+ activity within canine large intestine ????Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=19268670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19268670 #FOAvip English Wikipedia <ref>{{Cite pmid|19268670}}</ref> Heterogeneities in ICC Ca2+ activity within canine large intestine #MMPMID19268670 Lee HT; Hennig GW; Park KJ; Bayguinov PO; Ward SM; Sanders KM; Smith TK Gastroenterology 2009[Jun]; 136 (7): 2226-36 PMID19268670show ga Background & Aims: In human and canine colon, both slow (slow waves, 2?8/min) and fast (myenteric potential oscillations; MPOs, 16?20/min) electrical rhythms in the smooth muscle originate at the submucosal and myenteric borders, respectively. We used Ca2+ imaging to investigate whether ICC at these borders generated distinct rhythms. Methods: Segments of canine colon were pinned submucosal or myenteric surface uppermost, or cut in cross-section. Tissues were loaded with a Ca2+ indicator (fluo-4) and activity was monitored at 36.5±0.5°C using a CCD camera. Results: Rhythmic, biphasic Ca2+ transients (5?8/min), similar in waveform to electrical slow waves, propagated without decrement as a wave front through the ICC-SM network (2?5mm/s), decaying exponentially through the thickness of the CM. In contrast, rhythmic intracellular Ca2+ waves (~16/min) and spontaneous reductions in Ca2+ were observed in ICC-MY. Normally, intracellular Ca2+ waves were unsynchronized between adjacent ICC-MY, although excitatory nerve activity synchronized activity. In addition, spontaneous reductions in Ca2+ were observed that inhibited Ca2+ waves. L-NA (100µM; NO antagonist) blocked the reductions in Ca2+ and increased the frequency (~19/min) of intracellular Ca2+ waves within ICC-MY. Conclusions: ICC-SM form a tightly coupled network that is able to generate and propagate slow waves. In contrast, Ca2+ transients in ICC-MY, which are normally not synchronized, have a similar duration and frequency as MPOs. Like MPOs, their activity is inhibited by nitrergic nerves and synchronized by excitatory nerves. äHeterogeneities in ICC Ca2+ activity within canine large intestine (epmc).pdf DeepDyve Pubget Overpricing