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10.1186/s40478-016-0297-4 http://scihub22266oqcxt.onion/10.1186/s40478-016-0297-4 C4802600!4802600!27001057     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol+Commun 2016 ; 4 (ä): ä Nephropedia Template TP {{tp|p=27001057|t=2016. Pneumococcal meningitis: Clinical-pathological correlations (meningene-path) |pdf=|usr=}}{{27001057}} gab.com Text Pneumococcal meningitis: Clinical-pathological correlations (meningene-path) JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=27001057 #FOAvip Pneumococcal meningitis is associated with substantial mortality and morbidity. We systematically assessed brain histopathology of 31 patients who died of pneumococcal meningitis from a nationwide study (median age 67 years; 21 (67 %) were male) using a pathology score including inflammation and vascular damage. Of the 27 patients with known time from the admission to death, 14 patients died within 7 days of admission and 13 after 7 days of admission. Eleven of 25 (44 %) patients had been treated with adjunctive dexamethasone therapy. Observed pathological processes were inflammation of medium-large arteries in 30 brains (97 %), cerebral haemorrhage in 24 (77 %), cerebritis in 24 (77 %), thrombosis in 21 (68 %), infarction in 19 (61 %) and ventriculitis in 19 (of 28 cases, 68 %). Inflammation of medium-large arteries led to obstruction of the vascular lumen in 14 (of 31 cases, 45 %). Vascular inflammation was associated with infarction and thrombosis of brain parenchymal vessels. Hippocampal dentate gyrus apoptosis between patients treated with and without dexamethasone was similar (p?=?0.66); however, dexamethasone treated patients had higher total pathology score than non-dexamethasone treated patients (p?=?0.003). Our study shows that vascular damage is key in the process of brain damage in pneumococcal meningitis. Data and material of this study will be made open-access for translational research in pneumococcal meningitis (MeninGene-Path).Electronic supplementary material: The online version of this article (doi:10.1186/s40478-016-0297-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip Pneumococcal meningitis: Clinical-pathological correlations (meningene-path) ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=27001057 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27001057 #FOAvip English Wikipedia <ref>{{Cite pmid|27001057}}</ref> Pneumococcal meningitis: Clinical-pathological correlations (meningene-path) #MMPMID27001057 Engelen-Lee JY; Brouwer MC; Aronica E; van de Beek D Acta Neuropathol Commun 2016[]; 4 (ä): ä PMID27001057show ga Pneumococcal meningitis is associated with substantial mortality and morbidity. We systematically assessed brain histopathology of 31 patients who died of pneumococcal meningitis from a nationwide study (median age 67 years; 21 (67 %) were male) using a pathology score including inflammation and vascular damage. Of the 27 patients with known time from the admission to death, 14 patients died within 7 days of admission and 13 after 7 days of admission. Eleven of 25 (44 %) patients had been treated with adjunctive dexamethasone therapy. Observed pathological processes were inflammation of medium-large arteries in 30 brains (97 %), cerebral haemorrhage in 24 (77 %), cerebritis in 24 (77 %), thrombosis in 21 (68 %), infarction in 19 (61 %) and ventriculitis in 19 (of 28 cases, 68 %). Inflammation of medium-large arteries led to obstruction of the vascular lumen in 14 (of 31 cases, 45 %). Vascular inflammation was associated with infarction and thrombosis of brain parenchymal vessels. Hippocampal dentate gyrus apoptosis between patients treated with and without dexamethasone was similar (p?=?0.66); however, dexamethasone treated patients had higher total pathology score than non-dexamethasone treated patients (p?=?0.003). Our study shows that vascular damage is key in the process of brain damage in pneumococcal meningitis. Data and material of this study will be made open-access for translational research in pneumococcal meningitis (MeninGene-Path).Electronic supplementary material: The online version of this article (doi:10.1186/s40478-016-0297-4) contains supplementary material, which is available to authorized users. äPneumococcal meningitis: Clinical-pathological correlations (meningene(epmc).pdf DeepDyve Pubget Overpricing