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10.1007/s00018-008-8497-0

http://scihub22266oqcxt.onion/10.1007/s00018-008-8497-0
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C4802364!4802364!18818872
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suck abstract from ncbi

pmid18818872      Cell+Mol+Life+Sci 2008 ; 65 (21): 3383-98
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  • Murine endogenous retroviruses #MMPMID18818872
  • Stocking C; Kozak CA
  • Cell Mol Life Sci 2008[Nov]; 65 (21): 3383-98 PMID18818872show ga
  • Up to 10% of the mouse genome is comprised of endogenous retrovirus (ERV) sequences, and most represent the remains of ancient germ line infections. Our knowledge of the three distinct classes of ERVs is inversely correlated with their copy number, and their characterization has benefited from the availability of divergent wild mouse species and subspecies, and from ongoing analysis of the Mus genome sequence. In contrast to human ERVs, which are nearly all extinct, active mouse ERVs can still be found in all three ERV classes. The distribution and diversity of ERVs has been shaped by host-virus interactions over the course of evolution, but ERVs have also been pivotal in shaping the mouse genome by altering host genes through insertional mutagenesis, by adding novel regulatory and coding sequences, and by their co-option by host cells as retroviral resistance genes. We review mechanisms by which an adaptive coexistence has evolved. (Part of a Multi-author Review)
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