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10.1038/srep23528 http://scihub22266oqcxt.onion/10.1038/srep23528 C4802322!4802322!27000434     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27000434|t=2016. Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent |pdf=|usr=}}{{27000434}} gab.com Text Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27000434 #FOAvip Photoacoustic Tomography (PAT) is a deep-tissue imaging modality, with potential clinical applications in the diagnosis of arthritis, cancer and other disease conditions. Here, we identified Clofazimine (CFZ), a red-pigmented dye and anti-inflammatory FDA-approved drug, as a macrophage-targeting photoacoustic (PA) imaging agent. Spectroscopic experiments revealed that CFZ and its various protonated forms yielded optimal PAT signals at wavelengths ?450 to 540?nm. CFZ?s macrophage-targeting chemical and structural forms were detected with PA microscopy at a high contrast-to-noise ratio (CNR?>?22?dB) as well as with macroscopic imaging using synthetic gelatin phantoms. In vivo, natural and synthetic CFZ formulations also demonstrated significant anti-inflammatory activity. Finally, the injection of CFZ was monitored via a real-time ultrasound-photoacoustic (US-PA) dual imaging system in a live animal and clinically relevant human hand model. These results demonstrate an anti-inflammatory drug repurposing strategy, while identifying a new PA contrast agent with potential applications in the diagnosis and treatment of arthritis. Twit Text FOAVip Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27000434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27000434 #FOAvip English Wikipedia <ref>{{Cite pmid|27000434}}</ref> Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent #MMPMID27000434 Keswani RK; Tian C; Peryea T; Girish G; Wang X; Rosania GR Sci Rep 2016[]; 6 (ä): ä PMID27000434show ga Photoacoustic Tomography (PAT) is a deep-tissue imaging modality, with potential clinical applications in the diagnosis of arthritis, cancer and other disease conditions. Here, we identified Clofazimine (CFZ), a red-pigmented dye and anti-inflammatory FDA-approved drug, as a macrophage-targeting photoacoustic (PA) imaging agent. Spectroscopic experiments revealed that CFZ and its various protonated forms yielded optimal PAT signals at wavelengths ?450 to 540?nm. CFZ?s macrophage-targeting chemical and structural forms were detected with PA microscopy at a high contrast-to-noise ratio (CNR?>?22?dB) as well as with macroscopic imaging using synthetic gelatin phantoms. In vivo, natural and synthetic CFZ formulations also demonstrated significant anti-inflammatory activity. Finally, the injection of CFZ was monitored via a real-time ultrasound-photoacoustic (US-PA) dual imaging system in a live animal and clinically relevant human hand model. These results demonstrate an anti-inflammatory drug repurposing strategy, while identifying a new PA contrast agent with potential applications in the diagnosis and treatment of arthritis. äRepositioning Clofazimine as a Macrophage-Targeting Photoacoustic Cont(epmc).pdf DeepDyve Pubget Overpricing