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10.1038/srep23498 http://scihub22266oqcxt.onion/10.1038/srep23498 C4802218!4802218!27000966     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27000966|t=2016. Selection of urinary sediment miRNAs as specific biomarkers of IgA nephropathy |pdf=|usr=}}{{27000966}} gab.com Text Selection of urinary sediment miRNAs as specific biomarkers of IgA nephropathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27000966 #FOAvip The miRNAs in urinary sediment are easy to obtain, which provides a new approach to searching for non-invasive biomarkers of IgA nephropathy (IgAN). Compared with normal controls (n?=?3), 214 different miRNAs in the urinary sediment of IgAN (n?=?9) were found by miRNA chip assay. By quantitative PCR analysis, miR-25-3p, miR-144-3p and miR-486-5p were confirmed to be significantly higher in IgAN (n?=?93) than in the normal group (n?=?82) or disease control (n?=?40). These three miRNAs had good specificity and sensitivity for the diagnosis of IgAN by receiver operating characteristic curve analysis, in which the AUC value of miR-486-5p was the largest at 0.935. Urinary sediment miR-25-3p, miR-144-3p and miR-486-5p were demonstrated to be mainly derived from urinary erythrocytes, which were separated by CD235a magnetic beads. The increased expression of urinary erythrocyte miRNAs in IgAN patients was not associated with those in the blood erythrocytes. In addition, urinary supernatant microvesicles of miR-144-3p and miR-486-5p in the IgAN group were also significantly increased. This study showed that the miR-25-3p, miR-144-3p and miR-486-5p in urinary sediment were mainly derived from urinary erythrocytes, which could be non-invasive candidate biomarkers for IgA nephropathy. Twit Text FOAVip Selection of urinary sediment miRNAs as specific biomarkers of IgA nephropathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27000966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27000966 #FOAvip English Wikipedia <ref>{{Cite pmid|27000966}}</ref> Selection of urinary sediment miRNAs as specific biomarkers of IgA nephropathy #MMPMID27000966 Duan ZY; Cai Gy; Bu R; Lu Y; Hou K; Chen XM Sci Rep 2016[]; 6 (ä): ä PMID27000966show ga The miRNAs in urinary sediment are easy to obtain, which provides a new approach to searching for non-invasive biomarkers of IgA nephropathy (IgAN). Compared with normal controls (n?=?3), 214 different miRNAs in the urinary sediment of IgAN (n?=?9) were found by miRNA chip assay. By quantitative PCR analysis, miR-25-3p, miR-144-3p and miR-486-5p were confirmed to be significantly higher in IgAN (n?=?93) than in the normal group (n?=?82) or disease control (n?=?40). These three miRNAs had good specificity and sensitivity for the diagnosis of IgAN by receiver operating characteristic curve analysis, in which the AUC value of miR-486-5p was the largest at 0.935. Urinary sediment miR-25-3p, miR-144-3p and miR-486-5p were demonstrated to be mainly derived from urinary erythrocytes, which were separated by CD235a magnetic beads. The increased expression of urinary erythrocyte miRNAs in IgAN patients was not associated with those in the blood erythrocytes. In addition, urinary supernatant microvesicles of miR-144-3p and miR-486-5p in the IgAN group were also significantly increased. This study showed that the miR-25-3p, miR-144-3p and miR-486-5p in urinary sediment were mainly derived from urinary erythrocytes, which could be non-invasive candidate biomarkers for IgA nephropathy. äSelection of urinary sediment miRNAs as specific biomarkers of IgA nep(epmc).pdf DeepDyve Pubget Overpricing