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10.1038/ncomms10966 http://scihub22266oqcxt.onion/10.1038/ncomms10966 C4802181!4802181!26997247     free     free     free       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26997247|t=2016. Cajal bodies are linked to genome conformation |pdf=|usr=}}{{26997247}} gab.com Text Cajal bodies are linked to genome conformation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26997247 #FOAvip The mechanisms underlying nuclear body (NB) formation and their contribution to genome function are unknown. Here we examined the non-random positioning of Cajal bodies (CBs), major NBs involved in spliceosomal snRNP assembly and their role in genome organization. CBs are predominantly located at the periphery of chromosome territories at a multi-chromosome interface. Genome-wide chromosome conformation capture analysis (4C-seq) using CB-interacting loci revealed that CB-associated regions are enriched with highly expressed histone genes and U small nuclear or nucleolar RNA (sn/snoRNA) loci that form intra- and inter-chromosomal clusters. In particular, we observed a number of CB-dependent gene-positioning events on chromosome 1. RNAi-mediated disassembly of CBs disrupts the CB-targeting gene clusters and suppresses the expression of U sn/snoRNA and histone genes. This loss of spliceosomal snRNP production results in increased splicing noise, even in CB-distal regions. Therefore, we conclude that CBs contribute to genome organization with global effects on gene expression and RNA splicing fidelity. Twit Text FOAVip Cajal bodies are linked to genome conformation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26997247 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26997247 #FOAvip English Wikipedia <ref>{{Cite pmid|26997247}}</ref> Cajal bodies are linked to genome conformation #MMPMID26997247 Wang Q; Sawyer IA; Sung MH; Sturgill D; Shevtsov SP; Pegoraro G; Hakim O; Baek S; Hager GL; Dundr M Nat Commun 2016[]; 7 (ä): ä PMID26997247show ga The mechanisms underlying nuclear body (NB) formation and their contribution to genome function are unknown. Here we examined the non-random positioning of Cajal bodies (CBs), major NBs involved in spliceosomal snRNP assembly and their role in genome organization. CBs are predominantly located at the periphery of chromosome territories at a multi-chromosome interface. Genome-wide chromosome conformation capture analysis (4C-seq) using CB-interacting loci revealed that CB-associated regions are enriched with highly expressed histone genes and U small nuclear or nucleolar RNA (sn/snoRNA) loci that form intra- and inter-chromosomal clusters. In particular, we observed a number of CB-dependent gene-positioning events on chromosome 1. RNAi-mediated disassembly of CBs disrupts the CB-targeting gene clusters and suppresses the expression of U sn/snoRNA and histone genes. This loss of spliceosomal snRNP production results in increased splicing noise, even in CB-distal regions. Therefore, we conclude that CBs contribute to genome organization with global effects on gene expression and RNA splicing fidelity. äCajal bodies are linked to genome conformation (epmc).pdf DeepDyve Pubget Overpricing