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2015 ; 7
(4
): 184-9
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Effect of streptokinase on reperfusion after acute myocardial infarction and its
complications: an ex-post facto study
#MMPMID25946921
Taheri L
; Boroujeni AZ
; Kargar Jahromi M
; Charkhandaz M
; Hojat M
Glob J Health Sci
2015[Jan]; 7
(4
): 184-9
PMID25946921
show ga
INTRODUCTION: Emergency treatment of patients with acute myocardial infarction is
very important. Streptokinase in Iran is often as the only clot-busting
medication is used. The purpose of using streptokinase medication is to revive
the ischemic heart tissue, although has dangerous complications too. Therefore,
the present study aimed to determine the effect of streptokinase on reperfusion
after acute myocardial infarction and its complications, has been designed and
conducted. MATERIALS & METHODS: This is an Ex-post facto study. The study
population included patients who suffer from acute myocardial infarction. The
sample size was 300 patients, and 2 groups were matched, in variables of age,
sex, underlying disease, frequencies and area of MI. Data collection did by
researcher making questionnaire, that accept face and content validity by 10
expert researcher, the reliability was conducted with Spearman's test (r=0.85) by
Test-retest method. Data analysis did by SPSS software: V 12. FINDINGS: Mean of
EF in SK group was (46.15±8.11) and in control group was (43.11±12.57).
Significant relationship was seen between SK, arrhythmia occurring and improve EF
reperfusion by chi-square test (p=0.028), (p=0.020).The most arrhythmia in SK
group was Ventricular Tachycardia (20.7%). Significant statistical relation
between SK and mortality were found by Chi-square test (p=0.001). But a
meaningful statistical relation was not found between SK and pulmonary edema
incidence (p=0.071). CONCLUSIONS: Nurses of CCU should be aware about SK
complications such as hypotension, bleeding and arrhythmias. Proposed compare SK
and tissue plasminogen drug in reperfusion and complications effect.