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10.1038/ncomms11012 http://scihub22266oqcxt.onion/10.1038/ncomms11012 C4802055!4802055 !26987776     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26987776 &cmd=llinks): Failed to open stream: HTTP request failed! 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Differential TGF? pathway targeting by miR-122 in humans and mice affects liver cancer metastasis |pdf=|usr=}}{{26987776 }} gab.com Text Differential TGF pathway targeting by miR-122 in humans and mice affects liver cancer metastasis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26987776 #FOAvip Downregulation of a predominantly hepatocyte-specific miR-122 is associated with human liver cancer metastasis, whereas miR-122-deficient mice display normal liver function. Here we show a functional conservation of miR-122 in the TGF? pathway: miR-122 target site is present in the mouse but not human TGF?R1, whereas a noncanonical target site is present in the TGF?1 5'UTR in humans and other primates. Experimental switch of the miR-122 target between the receptor TGF?R1 and the ligand TGF?1 changes the metastatic properties of mouse and human liver cancer cells. High expression of TGF?1 in human primary liver tumours is associated with poor survival. We identify over 50 other miRNAs orthogonally targeting ligand/receptor pairs in humans and mice, suggesting that these are evolutionarily common events. These results reveal an evolutionary mechanism for miRNA-mediated gene regulation underlying species-specific physiological or pathological phenotype and provide a potentially valuable strategy for treating liver-associated diseases. Twit Text FOAVip Differential TGF pathway targeting by miR-122 in humans and mice affects liver cancer metastasis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26987776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26987776 #FOAvip English Wikipedia <ref>{{Cite pmid|26987776 }}</ref> Differential TGF? pathway targeting by miR-122 in humans and mice affects liver cancer metastasis #MMPMID26987776 Yin S ; Fan Y ; Zhang H ; Zhao Z ; Hao Y ; Li J ; Sun C ; Yang J ; Yang Z ; Yang X ; Lu J ; Xi JJ Nat Commun 2016[Mar]; 7 (ä): 11012 PMID26987776 show ga Downregulation of a predominantly hepatocyte-specific miR-122 is associated with human liver cancer metastasis, whereas miR-122-deficient mice display normal liver function. Here we show a functional conservation of miR-122 in the TGF? pathway: miR-122 target site is present in the mouse but not human TGF?R1, whereas a noncanonical target site is present in the TGF?1 5'UTR in humans and other primates. Experimental switch of the miR-122 target between the receptor TGF?R1 and the ligand TGF?1 changes the metastatic properties of mouse and human liver cancer cells. High expression of TGF?1 in human primary liver tumours is associated with poor survival. We identify over 50 other miRNAs orthogonally targeting ligand/receptor pairs in humans and mice, suggesting that these are evolutionarily common events. These results reveal an evolutionary mechanism for miRNA-mediated gene regulation underlying species-specific physiological or pathological phenotype and provide a potentially valuable strategy for treating liver-associated diseases. |*Signal Transduction/genetics [MESH] |5' Untranslated Regions/genetics [MESH] |Allografts [MESH] |Animals [MESH] |Base Pairing/genetics [MESH] |Base Sequence [MESH] |Cell Line [MESH] |Conserved Sequence/genetics [MESH] |Evolution, Molecular [MESH] |Genome [MESH] |Humans [MESH] |Liver Neoplasms/*genetics/*secondary [MESH] |Mice [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Molecular Sequence Data [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/metabolism [MESH] |Species Specificity [MESH] |Transforming Growth Factor beta/*metabolism [MESH]Differential TGF? pathway targeting by miR-122 in humans and mice affe(epmc).pdf DeepDyve Pubget Overpricing