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10.1038/ncomms10969 http://scihub22266oqcxt.onion/10.1038/ncomms10969 C4802043!4802043!26987298     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26987298|t=2016. Actin nucleation at the centrosome controls lymphocyte polarity |pdf=|usr=}}{{26987298}} gab.com Text Actin nucleation at the centrosome controls lymphocyte polarity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26987298 #FOAvip Cell polarity is required for the functional specialization of many cell types including lymphocytes. A hallmark of cell polarity is the reorientation of the centrosome that allows repositioning of organelles and vesicles in an asymmetric fashion. The mechanisms underlying centrosome polarization are not fully understood. Here we found that in resting lymphocytes, centrosome-associated Arp2/3 locally nucleates F-actin, which is needed for centrosome tethering to the nucleus via the LINC complex. Upon lymphocyte activation, Arp2/3 is partially depleted from the centrosome as a result of its recruitment to the immune synapse. This leads to a reduction in F-actin nucleation at the centrosome and thereby allows its detachment from the nucleus and polarization to the synapse. Therefore, F-actin nucleation at the centrosome?regulated by the availability of the Arp2/3 complex?determines its capacity to polarize in response to external stimuli. Twit Text FOAVip Actin nucleation at the centrosome controls lymphocyte polarity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26987298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26987298 #FOAvip English Wikipedia <ref>{{Cite pmid|26987298}}</ref> Actin nucleation at the centrosome controls lymphocyte polarity #MMPMID26987298 Obino D; Farina F; Malbec O; Sáez PJ; Maurin M; Gaillard J; Dingli F; Loew D; Gautreau A; Yuseff MI; Blanchoin L; Théry M; Lennon-Duménil AM Nat Commun 2016[]; 7 (ä): ä PMID26987298show ga Cell polarity is required for the functional specialization of many cell types including lymphocytes. A hallmark of cell polarity is the reorientation of the centrosome that allows repositioning of organelles and vesicles in an asymmetric fashion. The mechanisms underlying centrosome polarization are not fully understood. Here we found that in resting lymphocytes, centrosome-associated Arp2/3 locally nucleates F-actin, which is needed for centrosome tethering to the nucleus via the LINC complex. Upon lymphocyte activation, Arp2/3 is partially depleted from the centrosome as a result of its recruitment to the immune synapse. This leads to a reduction in F-actin nucleation at the centrosome and thereby allows its detachment from the nucleus and polarization to the synapse. Therefore, F-actin nucleation at the centrosome?regulated by the availability of the Arp2/3 complex?determines its capacity to polarize in response to external stimuli. äActin nucleation at the centrosome controls lymphocyte polarity (epmc).pdf DeepDyve Pubget Overpricing