Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.15252/embj.201592810 http://scihub22266oqcxt.onion/10.15252/embj.201592810 C4801947!4801947!26912724     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2016 ; 35 (6): 668-84 Nephropedia Template TP {{tp|p=26912724|t=2016. Wnt?induced deubiquitination FoxM1 ensures nucleus ??catenin transactivation |pdf=|usr=}}{{26912724}} gab.com Text Wnt induced deubiquitination FoxM1 ensures nucleus catenin transactivation JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26912724 #FOAvip A key step of Wnt signaling activation is the recruitment of ??catenin to the Wnt target?gene promoter in the nucleus, but its mechanisms are largely unknown. Here, we identified FoxM1 as a novel target of Wnt signaling, which is essential for ??catenin/TCF4 transactivation. GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. Wnt signaling activation inhibits FoxM1 phosphorylation by GSK3?Axin complex and leads to interaction between FoxM1 and deubiquitinating enzyme USP5, thereby deubiquitination and stabilization of FoxM1. FoxM1 accumulation in the nucleus promotes recruitment of ??catenin to Wnt target?gene promoter and activates the Wnt signaling pathway by protecting the ??catenin/TCF4 complex from ICAT inhibition. Subsequently, the USP5?FoxM1 axis abolishes the inhibitory effect of ICAT and is required for Wnt?mediated tumor cell proliferation. Therefore, Wnt?induced deubiquitination of FoxM1 represents a novel and critical mechanism for controlling canonical Wnt signaling and cell proliferation. Twit Text FOAVip Wnt induced deubiquitination FoxM1 ensures nucleus catenin transactivation ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26912724 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26912724 #FOAvip English Wikipedia <ref>{{Cite pmid|26912724}}</ref> Wnt?induced deubiquitination FoxM1 ensures nucleus ??catenin transactivation #MMPMID26912724 Chen Y; Li Y; Xue J; Gong A; Yu G; Zhou A; Lin K; Zhang S; Zhang N; Gottardi CJ; Huang S EMBO J 2016[Mar]; 35 (6): 668-84 PMID26912724show ga A key step of Wnt signaling activation is the recruitment of ??catenin to the Wnt target?gene promoter in the nucleus, but its mechanisms are largely unknown. Here, we identified FoxM1 as a novel target of Wnt signaling, which is essential for ??catenin/TCF4 transactivation. GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. Wnt signaling activation inhibits FoxM1 phosphorylation by GSK3?Axin complex and leads to interaction between FoxM1 and deubiquitinating enzyme USP5, thereby deubiquitination and stabilization of FoxM1. FoxM1 accumulation in the nucleus promotes recruitment of ??catenin to Wnt target?gene promoter and activates the Wnt signaling pathway by protecting the ??catenin/TCF4 complex from ICAT inhibition. Subsequently, the USP5?FoxM1 axis abolishes the inhibitory effect of ICAT and is required for Wnt?mediated tumor cell proliferation. Therefore, Wnt?induced deubiquitination of FoxM1 represents a novel and critical mechanism for controlling canonical Wnt signaling and cell proliferation. äWnt?induced deubiquitination FoxM1 ensures nucleus ??catenin transacti(epmc).pdf DeepDyve Pubget Overpricing