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10.15252/embj.201592649 http://scihub22266oqcxt.onion/10.15252/embj.201592649 C4801944!4801944!26884587     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2016 ; 35 (6): 685-98 Nephropedia Template TP {{tp|p=26884587|t=2016. Neutralization of pro?inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis |pdf=|usr=}}{{26884587}} gab.com Text Neutralization of pro inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26884587 #FOAvip Monocytes have emerged as critical driving force of acute inflammation. Here, we show that inhibition of Toll?like receptor 2(TLR2) dimerization by a TLR2 transmembrane peptide (TLR2?p) ameliorated DSS?induced colitis by interfering specifically with the activation of Ly6C+ monocytes without affecting their recruitment to the colon. We report that TLR2?p directly interacts with TLR2 within the membrane, leading to inhibition of TLR2?TLR6/1 assembly induced by natural ligands. This was associated with decreased levels of extracellular signal?regulated kinases (ERK) signaling and reduced secretion of pro?inflammatory cytokines, such as interleukin (IL)?6, IL?23, IL?12, and IL?1?. Altogether, our study provides insights into the essential role of TLR2 dimerization in the activation of pathogenic pro?inflammatory Ly6Chi monocytes and suggests that inhibition of this aggregation by TLR2?p might have therapeutic potential in the treatment of acute gut inflammation. Twit Text FOAVip Neutralization of pro inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26884587 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26884587 #FOAvip English Wikipedia <ref>{{Cite pmid|26884587}}</ref> Neutralization of pro?inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis #MMPMID26884587 Shmuel?Galia L; Aychek T; Fink A; Porat Z; Zarmi B; Bernshtein B; Brenner O; Jung S; Shai Y EMBO J 2016[Mar]; 35 (6): 685-98 PMID26884587show ga Monocytes have emerged as critical driving force of acute inflammation. Here, we show that inhibition of Toll?like receptor 2(TLR2) dimerization by a TLR2 transmembrane peptide (TLR2?p) ameliorated DSS?induced colitis by interfering specifically with the activation of Ly6C+ monocytes without affecting their recruitment to the colon. We report that TLR2?p directly interacts with TLR2 within the membrane, leading to inhibition of TLR2?TLR6/1 assembly induced by natural ligands. This was associated with decreased levels of extracellular signal?regulated kinases (ERK) signaling and reduced secretion of pro?inflammatory cytokines, such as interleukin (IL)?6, IL?23, IL?12, and IL?1?. Altogether, our study provides insights into the essential role of TLR2 dimerization in the activation of pathogenic pro?inflammatory Ly6Chi monocytes and suggests that inhibition of this aggregation by TLR2?p might have therapeutic potential in the treatment of acute gut inflammation. äNeutralization of pro?inflammatory monocytes by targeting TLR2 dimeriz(epmc).pdf DeepDyve Pubget Overpricing