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2016 ; 11
(3
): e0152088
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Comparing the Curative Effects between Femtosecond Laser-Assisted Cataract
Surgery and Conventional Phacoemulsification Surgery: A Meta-Analysis
#MMPMID26999612
Chen X
; Chen K
; He J
; Yao K
PLoS One
2016[]; 11
(3
): e0152088
PMID26999612
show ga
PURPOSE: To compare the outcomes of femtosecond laser-assisted cataract surgery
(FLACS) with those of conventional phacoemulsification surgery (CPS) for
age-related cataracts. METHODS: A comprehensive literature search of PubMed,
EMBASE, and the Cochrane Controlled Trials Register was conducted to identify
randomized controlled trials (RCT) and comparative cohort studies comparing FLACS
with CPS. Endothelial cell loss percentage (ECL%), central corneal thickness
(CCT), corrected and uncorrected distant visual acuity (CDVA and UDVA), and mean
absolute error (MAE) of refraction were used as primary outcomes. Secondary
outcomes included surgically induced astigmatism (SIA), mean effective
phacoemulsification time (EPT), phacoemulsification power and circularity of the
capsulorhexis. RESULTS: Nine RCTs and fifteen cohort studies including 4,903 eyes
(2,861 in the FLACS group and 2,072 in the CPS group) were identified. There were
significant differences between the two groups in ECL% at one week, about one
month and three months postoperatively, in CCT at one day, about one month
postoperatively and at the final follow-up, in CDVA at one week postoperatively,
and in UDVA at the final follow-up. Significant differences were also observed in
MAE, EPT, phacoemulsification power, and the circularity of capsulorhexis.
However, no significant differences were observed in CDVA at one week
postoperatively or in surgically induced astigmatism. CONCLUSIONS: Compared to
CPS, FLACS is a safer and more effective method for reducing endothelial cell
loss and postoperative central corneal thickening as well as achieving better and
faster visual rehabilitation and refractive outcomes. However, there is no
difference in final CDVA and surgically induced astigmatism between the two
groups.