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2016 ; 11
(3
): e0151674
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The Phenotypic Characterization of the Human Renal Mononuclear Phagocytes Reveal
a Co-Ordinated Response to Injury
#MMPMID26999595
Leone DA
; Kozakowski N
; Kornauth C
; Waidacher T
; Neudert B
; Loeffler AG
; Haitel A
; Rees AJ
; Kain R
PLoS One
2016[]; 11
(3
): e0151674
PMID26999595
show ga
Mammalian tissues contain networks of mononuclear phagocytes (MPh) that sense
injury and orchestrate the response to it. In mice, this is affected by distinct
populations of dendritic cells (DC), monocytes and macrophages and recent studies
suggest the same is true for human skin and intestine but little is known about
the kidney. Here we describe the analysis of MPh populations in five human
kidneys and show they are highly heterogeneous and contain discrete populations
of DC, monocytes and macrophages. These include: plasmacytoid DC (CD303+) and
both types of conventional DC-cDC1 (CD141+ cells) and CD2 (CD1c+ cells);
classical, non-classical and intermediate monocytes; and macrophages including a
novel population of CD141+ macrophages clearly distinguishable from cDC1 cells.
The relative size of the MPh populations differed between kidneys: the pDC
population was bi-modally distributed being less than 2% of DC in two kidneys
without severe injury and over 35% in the remaining three with low grade injury
in the absence of morphological evidence of inflammation. There were profound
differences in the other MPh populations in kidneys with high and low numbers of
pDC. Thus, cDC1 cells were abundant (55 and 52.3%) when pDC were sparse and
sparse (12.8-12.5%) when pDC were abundant, whereas the proportions of cDC2 cells
and classical monocytes increased slightly in pDC high kidneys. We conclude that
MPh are highly heterogeneous in human kidneys and that pDC infiltration
indicative of low-grade injury does not occur in isolation but is part of a
co-ordinated response affecting all renal DC, monocyte and macrophage
populations.
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