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10.1161/CIRCRESAHA.116.308468 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.116.308468 C4801122!4801122!26987913     free     free     free       Circ+Res 2016 ; 118 (6): 920-2 Nephropedia Template TP {{tp|p=26987913|t=2016. Healing a Heart through Genetic Intervention |pdf=|usr=}}{{26987913}} gab.com Text Healing a Heart through Genetic Intervention JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=26987913 #FOAvip A recent manuscript from Eric Olson?s group outlines the development of an important new tool that should catalyze the cardiovascular community?s ability to create new animal models containing genetically engineered genes and proteins specifically in the cardiomyocyte (CM) population. Olson and colleagues utilized a CM-specific promoter to express a critical component of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated (Cas)9 genomic editing system. The ? myosin heavy chain gene (myh6) promoter was used to drive high levels of CM-specific Cas9 expression. Subsequently, Adeno-Associated Virus (AAV) was used to deliver single-guide RNA (sgRNA) against the myh6 locus and they were able to show efficient gene editing at the locus, establishing proof of principle for what the authors term ?cardioediting,? a strategy for revising a specific locus in the CMs at any time post birth. Twit Text FOAVip Healing a Heart through Genetic Intervention ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=26987913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26987913 #FOAvip English Wikipedia <ref>{{Cite pmid|26987913}}</ref> Healing a Heart through Genetic Intervention #MMPMID26987913 James J; Robbins J Circ Res 2016[Mar]; 118 (6): 920-2 PMID26987913show ga A recent manuscript from Eric Olson?s group outlines the development of an important new tool that should catalyze the cardiovascular community?s ability to create new animal models containing genetically engineered genes and proteins specifically in the cardiomyocyte (CM) population. Olson and colleagues utilized a CM-specific promoter to express a critical component of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated (Cas)9 genomic editing system. The ? myosin heavy chain gene (myh6) promoter was used to drive high levels of CM-specific Cas9 expression. Subsequently, Adeno-Associated Virus (AAV) was used to deliver single-guide RNA (sgRNA) against the myh6 locus and they were able to show efficient gene editing at the locus, establishing proof of principle for what the authors term ?cardioediting,? a strategy for revising a specific locus in the CMs at any time post birth. äHealing a Heart through Genetic Intervention (epmc).pdf DeepDyve Pubget Overpricing