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http://scihub22266oqcxt.onion/ C4801034!4801034!10762633     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Oncol 2000 ; 16 (5): 971-8 Nephropedia Template TP {{tp|p=10762633|t=2000. Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs |pdf=|usr=}}{{10762633}} gab.com Text Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=10762633 #FOAvip Caffeine inhibits the G2 checkpoint activated by DNA damage and enhances the toxicity of DNA-damaging agents towards p53-defective cancer cells. The relationship between structure and G2 checkpoint inhibition was determined for 56 caffeine analogs. Replacement of the methyl group at position 3 or 7 resulted in loss of activity, while replacement at position 1 by ethyl or propyl increased activity slightly. 8-Substituted caffeines retained activity, but were relatively insoluble. The structure-activity profile did not resemble those for other known pharmacological activities of caffeine. The active analogs also potentiated the killing of p53-defective cells by ionizing radiation, but none was as effective as caffeine. Twit Text FOAVip Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=10762633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10762633 #FOAvip English Wikipedia <ref>{{Cite pmid|10762633}}</ref> Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs #MMPMID10762633 Jiang X; Lim LY; Daly JW; Li AH; Jacobson KA; Roberge M Int J Oncol 2000[May]; 16 (5): 971-8 PMID10762633show ga Caffeine inhibits the G2 checkpoint activated by DNA damage and enhances the toxicity of DNA-damaging agents towards p53-defective cancer cells. The relationship between structure and G2 checkpoint inhibition was determined for 56 caffeine analogs. Replacement of the methyl group at position 3 or 7 resulted in loss of activity, while replacement at position 1 by ethyl or propyl increased activity slightly. 8-Substituted caffeines retained activity, but were relatively insoluble. The structure-activity profile did not resemble those for other known pharmacological activities of caffeine. The active analogs also potentiated the killing of p53-defective cells by ionizing radiation, but none was as effective as caffeine. äStructure-activity relationships for G2 checkpoint inhibition by caffe(epmc).pdf DeepDyve Pubget Overpricing