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2016 ; 17
(ä): 30
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English Wikipedia
Renal abnormalities among HIV infected children at Muhimbili National Hospital
(MNH)-Dar es Salaam, Tanzania
#MMPMID27000018
Fredrick F
; Francis JM
; Ruggajo PJ
; Maro EE
BMC Nephrol
2016[Mar]; 17
(ä): 30
PMID27000018
show ga
BACKGROUND: Human Immunodeficiency Virus infection is a multisystem disease that
contributes to significant morbidity. Renal involvement is reported to be common
among patients with HIV. This study was carried out to determine renal
involvement using simple bedside tests combined with ultrasonography examination.
METHODS: We recruited 240 children from the HIV clinic at Muhimbili National
Hospital. Data were collected using structured questionnaires and included
demographic, clinical information, radiological tests; renal ultrasound and
laboratory tests; serum creatinine, white blood cells, CD4+ counts and percent,
urine for microalbuminuria and proteinuria. RESULTS: Microalbuminuria and
proteinuria were present in 20.4 % and 7.1 % respectively. Significantly higher
prevalence of microalbuminuria (p?0.01) and proteinuria p?0.01) were noted
with low CD4 percent (<25 %). Lower mean CD4+ count were noted among children
with microalbuminuria [937.4?±?595.3 cells/?L vs 1164.7?±?664.3 cell/?L,
(p?0.05)] and proteinuria [675.5?±?352.3 cells/?L vs 1152?±?662 cells/?L
(p?0.001)]. Fourteen (5.8 %) HIV infected children had estimated glomerular
filtration rate (eGFR of 30-59) consistent with severe renal impairment.
Increased cortical echogenicity was noted in 69/153 (39.2 %) of participants who
had ultrasound examination. CONCLUSION: Microalbuminuria, proteinuria and renal
dysfunction were noted to be prevalent among HIV infected children indicating the
need to consider routine screening of renal complications in these children.